A nonlinear relationship between low-density-lipoprotein cholesterol levels and atrial fibrillation among patients with hypertension in China.
Atrial fibrillation
hypertension
low-density-lipoprotein cholesterol
Journal
Annals of palliative medicine
ISSN: 2224-5839
Titre abrégé: Ann Palliat Med
Pays: China
ID NLM: 101585484
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
19
02
2020
accepted:
14
07
2020
pubmed:
21
8
2020
medline:
15
5
2021
entrez:
22
8
2020
Statut:
ppublish
Résumé
The association between low-density-lipoprotein cholesterol (LDL-C) and atrial fibrillation (AF) in hypertensive population remains controversial. Therefore, we explored the relationship between LDL-C and AF among patients with hypertension in a Chinese community. This is a retrospective cross-sectional study that enrolled 7808 hypertensive patients between January 2013 and December 2013 in Guangdong, China. AF was diagnosed by 12-lead electrocardiogram (ECG) or self-reported status. LDL-C value were categorized by quartiles. Univariate and multivariate logistic regression were performed to examine the relation between LDL-C and AF. LDL-C values were expressed in continuous (every 1 mg/dL increment) or categorical variables in each regression model. Among 7,808 (47.1% man, with mean age 62.3 years) participants, 78 AF cases were identified. In multivariate logistic regression, when LDL-C was presented as continuous variable, it was inversely associated with the occurrence of new onset AF (OR =0.99, 95% CI: 0.98, 1.00; P=0.018). Meanwhile, when LDL-C was presented as categorical variable, the negative association between LDL-C and AF was attenuated after adjusting for confounders. Adjusted restricted cubic spline demonstrated a non-linear correlation between LDL-C and AF. Lower levels of LDL-C was associated with increased incidence of AF in a Chinese community hypertensive population.
Sections du résumé
BACKGROUND
BACKGROUND
The association between low-density-lipoprotein cholesterol (LDL-C) and atrial fibrillation (AF) in hypertensive population remains controversial. Therefore, we explored the relationship between LDL-C and AF among patients with hypertension in a Chinese community.
METHODS
METHODS
This is a retrospective cross-sectional study that enrolled 7808 hypertensive patients between January 2013 and December 2013 in Guangdong, China. AF was diagnosed by 12-lead electrocardiogram (ECG) or self-reported status. LDL-C value were categorized by quartiles. Univariate and multivariate logistic regression were performed to examine the relation between LDL-C and AF. LDL-C values were expressed in continuous (every 1 mg/dL increment) or categorical variables in each regression model.
RESULTS
RESULTS
Among 7,808 (47.1% man, with mean age 62.3 years) participants, 78 AF cases were identified. In multivariate logistic regression, when LDL-C was presented as continuous variable, it was inversely associated with the occurrence of new onset AF (OR =0.99, 95% CI: 0.98, 1.00; P=0.018). Meanwhile, when LDL-C was presented as categorical variable, the negative association between LDL-C and AF was attenuated after adjusting for confounders. Adjusted restricted cubic spline demonstrated a non-linear correlation between LDL-C and AF.
CONCLUSIONS
CONCLUSIONS
Lower levels of LDL-C was associated with increased incidence of AF in a Chinese community hypertensive population.
Identifiants
pubmed: 32819119
pii: apm-20-451
doi: 10.21037/apm-20-451
doi:
Substances chimiques
Lipoproteins
0
lipoprotein cholesterol
0
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM