Pulmonary Artery Denervation for Patients With Residual Pulmonary Hypertension After Pulmonary Endarterectomy.
Cardiac Catheterization
/ methods
Denervation
/ instrumentation
Endarterectomy
/ adverse effects
Enzyme Activators
/ administration & dosage
Female
Humans
Hypertension, Pulmonary
/ etiology
Male
Middle Aged
Pulmonary Artery
/ innervation
Pulmonary Embolism
/ complications
Pulmonary Wedge Pressure
/ physiology
Pyrazoles
/ administration & dosage
Pyrimidines
/ administration & dosage
Surgery, Computer-Assisted
/ methods
Treatment Outcome
Vascular Resistance
/ physiology
Walk Test
/ methods
chronic thromboembolic pulmonary hypertension
pulmonary artery denervation
pulmonary hypertension
remote magnetic navigation
Journal
Journal of the American College of Cardiology
ISSN: 1558-3597
Titre abrégé: J Am Coll Cardiol
Pays: United States
ID NLM: 8301365
Informations de publication
Date de publication:
25 08 2020
25 08 2020
Historique:
received:
30
03
2020
revised:
24
06
2020
accepted:
25
06
2020
entrez:
22
8
2020
pubmed:
21
8
2020
medline:
2
2
2021
Statut:
ppublish
Résumé
Pulmonary artery denervation (PADN) procedure has not been applied to patients with residual chronic thromboembolic pulmonary hypertension (CTEPH) after pulmonary endarterectomy (PEA). This study sought to assess the safety and efficacy of PADN using remote magnetic navigation in patients with residual CTEPH after PEA. Fifty patients with residual CTEPH despite medical therapy at least 6 months after PEA, who had mean pulmonary artery pressure ≥25 mm Hg or pulmonary vascular resistance (PVR) > 400 dyn‧s‧cm After PADN procedure, 2 patients (1 in each group) developed groin hematoma that resolved without any consequences. At 12 months, mean PVR reduction was 258 ± 135 dyn‧s‧cm PADN in patients with residual CTEPH resulted in substantial reduction of PVR at 12 months of follow-up, accompanied by improved 6-min walk test.
Sections du résumé
BACKGROUND
Pulmonary artery denervation (PADN) procedure has not been applied to patients with residual chronic thromboembolic pulmonary hypertension (CTEPH) after pulmonary endarterectomy (PEA).
OBJECTIVES
This study sought to assess the safety and efficacy of PADN using remote magnetic navigation in patients with residual CTEPH after PEA.
METHODS
Fifty patients with residual CTEPH despite medical therapy at least 6 months after PEA, who had mean pulmonary artery pressure ≥25 mm Hg or pulmonary vascular resistance (PVR) > 400 dyn‧s‧cm
RESULTS
After PADN procedure, 2 patients (1 in each group) developed groin hematoma that resolved without any consequences. At 12 months, mean PVR reduction was 258 ± 135 dyn‧s‧cm
CONCLUSIONS
PADN in patients with residual CTEPH resulted in substantial reduction of PVR at 12 months of follow-up, accompanied by improved 6-min walk test.
Identifiants
pubmed: 32819465
pii: S0735-1097(20)35868-X
doi: 10.1016/j.jacc.2020.06.064
pii:
doi:
Substances chimiques
Enzyme Activators
0
Pyrazoles
0
Pyrimidines
0
riociguat
RU3FE2Y4XI
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
916-926Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2020 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.