GRL-0920, an Indole Chloropyridinyl Ester, Completely Blocks SARS-CoV-2 Infection.
Amino Acid Sequence
Animals
Antiviral Agents
/ pharmacology
Betacoronavirus
/ drug effects
COVID-19
Chlorocebus aethiops
Chloroquine
/ pharmacology
Coronavirus 3C Proteases
Coronavirus Infections
/ drug therapy
Cysteine Endopeptidases
/ chemistry
Indoles
/ chemistry
Models, Molecular
Pandemics
Pneumonia, Viral
/ drug therapy
SARS-CoV-2
Vero Cells
Viral Nonstructural Proteins
/ antagonists & inhibitors
COVID-19
SARS-CoV-2
antiviral agents
main protease
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
20 08 2020
20 08 2020
Historique:
entrez:
22
8
2020
pubmed:
21
8
2020
medline:
9
9
2020
Statut:
epublish
Résumé
We assessed various newly generated compounds that target the main protease (M
Identifiants
pubmed: 32820005
pii: mBio.01833-20
doi: 10.1128/mBio.01833-20
pmc: PMC7441487
pii:
doi:
Substances chimiques
Antiviral Agents
0
Indoles
0
Viral Nonstructural Proteins
0
Chloroquine
886U3H6UFF
Cysteine Endopeptidases
EC 3.4.22.-
Coronavirus 3C Proteases
EC 3.4.22.28
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : HHSN272201700006C
Pays : United States
Commentaires et corrections
Type : CommentIn
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