SOSTDC1-producing follicular helper T cells promote regulatory follicular T cell differentiation.

Adaptor Proteins, Signal Transducing / genetics Animals B-Lymphocytes / immunology Cell Differentiation / genetics Germinal Center / immunology Lymphocyte Activation / genetics Lymphocyte Count Mice Mice, Mutant Strains T-Lymphocytes, Helper-Inducer / immunology T-Lymphocytes, Regulatory / immunology Wnt Proteins / metabolism beta Catenin / metabolism

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
21 08 2020
Historique:
received: 20 12 2019
accepted: 12 06 2020
entrez: 22 8 2020
pubmed: 21 8 2020
medline: 22 9 2020
Statut: ppublish

Résumé

Germinal center (GC) responses potentiate the generation of follicular regulatory T (T

Identifiants

DOI: 10.1126/science.aba6652 PMID: 32820125
pubmed: 32820125
pii: 369/6506/984
doi: 10.1126/science.aba6652
doi:

Substances chimiques

Adaptor Proteins, Signal Transducing 0
Sostdc1 protein, mouse 0
Wnt Proteins 0
beta Catenin 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

984-988

Informations de copyright

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Auteurs

Xin Wu (X)

Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, P. R. China.
ORCID: 0000-0002-0767-0141

Yun Wang (Y)

Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, P. R. China.

Rui Huang (R)

Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, P. R. China.

Qujing Gai (Q)

Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, P. R. China.

Haofei Liu (H)

Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, P. R. China.

Meimei Shi (M)

Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, P. R. China.

Xiang Zhang (X)

Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, P. R. China.

Yonglin Zuo (Y)

Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, P. R. China.

Longjuan Chen (L)

Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, P. R. China.

Qiwen Zhao (Q)

Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, P. R. China.

Yu Shi (Y)

Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, P. R. China.

Fengchao Wang (F)

State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University (Army Medical University), Chongqing 400038, P. R. China.
ORCID: 0000-0003-0766-2173

Xiaowei Yan (X)

Institute for Systems Biology, Seattle, WA 98103, USA.
ORCID: 0000-0003-4215-1395

Huiping Lu (H)

Institute for Immunology and School of Medicine, Tsinghua University, Beijing 100084, P. R. China.

Senlin Xu (S)

Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, P. R. China.

Xiaohong Yao (X)

Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, P. R. China.

Lin Chen (L)

State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University (Army Medical University), Chongqing 400038, P. R. China.
ORCID: 0000-0001-7764-9412

Xia Zhang (X)

Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, P. R. China.
ORCID: 0000-0002-9040-1486

Qiang Tian (Q)

Institute for Systems Biology, Seattle, WA 98103, USA.

Ziyan Yang (Z)

Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, 250012, P. R. China.

Bo Zhong (B)

Medical Research Institute, School of Medicine, Wuhan University, Wuhan, 430071, P. R. China.
ORCID: 0000-0002-3832-2895

Chen Dong (C)

Institute for Immunology and School of Medicine, Tsinghua University, Beijing 100084, P. R. China.
ORCID: 0000-0002-0084-9130

Yan Wang (Y)

Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, P. R. China. xindongliu@hotmail.com bianxiuwu@263.net wang_yan1977@hotmail.com.
ORCID: 0000-0002-8150-5486

Xiu-Wu Bian (XW)

Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, P. R. China. xindongliu@hotmail.com bianxiuwu@263.net wang_yan1977@hotmail.com.
ORCID: 0000-0003-4383-0197

Xindong Liu (X)

Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, P. R. China. xindongliu@hotmail.com bianxiuwu@263.net wang_yan1977@hotmail.com.
ORCID: 0000-0002-2465-0337

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › SOSTDC1-producing follicular helper T cells...
questionsmedicales.fr › Eucaryotes › Animaux › SOSTDC1-producing follicular helper T cells...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › SOSTDC1-producing follicular helper T cells...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › SOSTDC1-producing follicular helper T cells...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Noeuds lymphatiques › Centre germinatif › SOSTDC1-producing follicular helper T cells...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › SOSTDC1-producing follicular helper T cells...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémogramme › Numération des leucocytes › Numération des lymphocytes › SOSTDC1-producing follicular helper T cells...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › SOSTDC1-producing follicular helper T cells...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › SOSTDC1-producing follicular helper T cells...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › SOSTDC1-producing follicular helper T cells...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › SOSTDC1-producing follicular helper T cells...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de type Wingless › SOSTDC1-producing follicular helper T cells...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › bêta-Caténine › SOSTDC1-producing follicular helper T cells...