Thickness of the cerebral cortex shows positive association with blood levels of triacylglycerols carrying 18-carbon fatty acids.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
20 08 2020
20 08 2020
Historique:
received:
15
03
2020
accepted:
30
07
2020
entrez:
22
8
2020
pubmed:
21
8
2020
medline:
23
6
2021
Statut:
epublish
Résumé
Perturbations in fatty acid (FA) metabolism as well as thinning of the cerebral cortex have been associated with cognitive decline in the elderly. Predominant FAs in the brain are docosahexaenoic acid (DHA) and arachidonic acid (ARA). Approximately 2-8% of esterified DHA and 3-5% of esterified ARA in the brain are replaced daily. DHA and ARA are derivatives of 18-carbon essential FAs, α-linolenic acid and linoleic acid, that must be imported into the brain from the circulation. In blood, FAs are primarily transported in triacylglycerols (TAGs) from which they can be released at the blood-brain-barrier and transported inside the brain. We show that circulating levels of TAGs carrying 18-carbon FAs are positively associated with cortical thickness in middle-aged adults. These associations are stronger in cortical regions with higher expression of genes regulating long-chain FA metabolism and cellular membranes, and cortical thickness in the same regions may be related to cognitive performance.
Identifiants
pubmed: 32820227
doi: 10.1038/s42003-020-01189-5
pii: 10.1038/s42003-020-01189-5
pmc: PMC7441395
doi:
Substances chimiques
Biomarkers
0
Fatty Acids
0
Triglycerides
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
456Subventions
Organisme : NIA NIH HHS
ID : R01 AG056726
Pays : United States
Organisme : CIHR
Pays : Canada
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