Spontaneous mutations in the single
Cancer genomics
Molecular medicine
Journal
NPJ genomic medicine
ISSN: 2056-7944
Titre abrégé: NPJ Genom Med
Pays: England
ID NLM: 101685193
Informations de publication
Date de publication:
2020
2020
Historique:
received:
24
06
2019
accepted:
13
11
2019
entrez:
22
8
2020
pubmed:
22
8
2020
medline:
22
8
2020
Statut:
epublish
Résumé
Tumor mutation burden (TMB) is an emerging biomarker, whose calculation requires targeted sequencing of many genes. We investigated if the measurement of mutation counts within a single gene is representative of TMB. Whole-exome sequencing (WES) data from the pan-cancer cohort (
Identifiants
pubmed: 32821429
doi: 10.1038/s41525-019-0107-6
pii: 107
pmc: PMC7424531
doi:
Types de publication
Journal Article
Langues
eng
Pagination
33Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing interests.
Références
Cell Syst. 2018 Mar 28;6(3):271-281.e7
pubmed: 29596782
Science. 2015 Apr 3;348(6230):124-8
pubmed: 25765070
Transl Lung Cancer Res. 2018 Dec;7(6):661-667
pubmed: 30505710
Genome Med. 2017 Apr 19;9(1):34
pubmed: 28420421
Crit Rev Oncol Hematol. 2006 Jul;59(1):1-14
pubmed: 16600619
JAMA. 2011 Oct 12;306(14):1557-65
pubmed: 21990299
Curr Biol. 1999 Jan 28;9(2):R62-5
pubmed: 10021355
N Engl J Med. 1988 Sep 1;319(9):525-32
pubmed: 2841597
Nat Methods. 2010 Apr;7(4):248-9
pubmed: 20354512
Database (Oxford). 2011 Jul 23;2011:bar030
pubmed: 21785142
Cell. 1996 Oct 18;87(2):159-70
pubmed: 8861899
Nature. 2013 Jul 11;499(7457):214-218
pubmed: 23770567
Sci Rep. 2015 Jul 27;5:12566
pubmed: 26212640
N Engl J Med. 2014 Dec 4;371(23):2189-2199
pubmed: 25409260
Nucleic Acids Res. 2003 Jul 1;31(13):3812-4
pubmed: 12824425
Oncotarget. 2015 Oct 27;6(33):34221-7
pubmed: 26439694
Oncogene. 1998 Aug 20;17(7):835-43
pubmed: 9780000
Genome Res. 2018 Nov;28(11):1747-1756
pubmed: 30341162
Bioinformatics. 2010 Mar 1;26(5):589-95
pubmed: 20080505
Genome Biol. 2019 May 30;20(1):111
pubmed: 31146781
Nat Med. 1996 Jun;2(6):630-1
pubmed: 8640546
Genome Biol. 2016 Jun 06;17(1):122
pubmed: 27268795
Genome Res. 2010 Sep;20(9):1297-303
pubmed: 20644199
Int J Cancer. 2019 Feb 15;144(4):848-858
pubmed: 30238975
Genome Res. 2010 Apr;20(4):447-57
pubmed: 20103589
BMC Med Genomics. 2014 Dec 03;7:64
pubmed: 25466818
Brief Bioinform. 2011 May;12(3):203-14
pubmed: 21324971
J Clin Oncol. 2018 Mar 1;36(7):631-632
pubmed: 29337637
Nat Genet. 2003 Jul;34(3):267-73
pubmed: 12808457
Nature. 2012 Jul 18;487(7407):330-7
pubmed: 22810696
NPJ Genom Med. 2018 Apr 30;3:12
pubmed: 29736260
J Mol Diagn. 2019 Mar;21(2):241-250
pubmed: 30389464
J Clin Oncol. 2018 Mar 1;36(7):633-641
pubmed: 29337640