Established and Emerging Mechanisms of Diabetic Cardiomyopathy.
Diabetes mellitus
Diabetic cardiomyopathy
Heart failure
Journal
Journal of lipid and atherosclerosis
ISSN: 2287-2892
Titre abrégé: J Lipid Atheroscler
Pays: Korea (South)
ID NLM: 101610890
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
01
03
2019
revised:
18
04
2019
accepted:
18
04
2019
entrez:
22
8
2020
pubmed:
1
5
2019
medline:
1
5
2019
Statut:
ppublish
Résumé
Diabetes mellitus increases the risk for the development of heart failure even in the absence of coronary artery disease and hypertension, a cardiac entity termed diabetic cardiomyopathy (DC). Clinically, DC is increasingly recognized and typically characterized by concentric cardiac hypertrophy and diastolic dysfunction, ultimately resulting in heart failure with preserved ejection fraction (HFpEF) and potentially even heart failure with reduced ejection fraction (HFrEF). Numerous molecular mechanisms have been proposed to underlie the alterations in myocardial structure and function in DC, many of which show similar alterations in the failing heart. Well investigated and established mechanisms of DC include increased myocardial fibrosis, enhanced apoptosis, oxidative stress, impaired intracellular calcium handling, substrate metabolic alterations, and inflammation, among others. In addition, a number of novel mechanisms that receive increasing attention have been identified in recent years, including autophagy, dysregulation of microRNAs, epigenetic mechanisms, and alterations in mitochondrial protein acetylation, dynamics and quality control. This review aims to provide an overview and update of established underlying mechanisms of DC, as well as a discussion of recently identified and emerging mechanisms that may also contribute to the structural and functional alterations in DC.
Identifiants
pubmed: 32821697
doi: 10.12997/jla.2019.8.1.26
pmc: PMC7379081
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
26-47Informations de copyright
Copyright © 2019 The Korean Society of Lipid and Atherosclerosis.
Déclaration de conflit d'intérêts
Conflict of Interest: The authors have no conflicts of interest to declare.
Références
J Mol Cell Cardiol. 2014 Jun;71:71-80
pubmed: 24513079
Redox Biol. 2016 Dec;10:200-205
pubmed: 27810734
Diabetes Metab Res Rev. 2012 Jul;28(5):409-17
pubmed: 22389139
Cardiovasc Ther. 2015 Jun;33(3):89-97
pubmed: 25781190
J Lipid Res. 2008 Oct;49(10):2101-12
pubmed: 18515784
PLoS One. 2014 Jan 09;9(1):e85078
pubmed: 24416343
J Clin Invest. 2002 Jan;109(1):121-30
pubmed: 11781357
Cardiovasc Res. 2012 Mar 1;93(3):445-53
pubmed: 22198507
Int J Endocrinol. 2014;2014:847827
pubmed: 24744784
Am J Physiol Heart Circ Physiol. 2003 Jan;284(1):H122-32
pubmed: 12485818
Cell Rep. 2016 Jun 7;15(10):2200-2213
pubmed: 27239029
Cell Metab. 2016 Aug 9;24(2):269-82
pubmed: 27508874
Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12746-51
pubmed: 11070088
Gynecol Oncol Res Pract. 2017 Nov 29;4:18
pubmed: 29214031
Proc Natl Acad Sci U S A. 2015 May 12;112(19):6050-5
pubmed: 25918408
Diabetes. 2007 Oct;56(10):2457-66
pubmed: 17623815
Nat Med. 2007 May;13(5):619-24
pubmed: 17450150
J Diabetes Res. 2016;2016:6143129
pubmed: 26770988
J Biol Chem. 2003 Nov 7;278(45):44230-7
pubmed: 12941958
J Mol Cell Cardiol. 2007 Jan;42(1):234-46
pubmed: 17027851
Diabetes. 1985 Nov;34(11):1075-81
pubmed: 4043556
FASEB J. 2008 Oct;22(10):3549-60
pubmed: 18606865
Immunology. 2010 Jul;130(3):329-36
pubmed: 20465574
Cell Metab. 2019 May 7;29(5):1119-1134.e12
pubmed: 30745182
Circulation. 2000 May 16;101(19):2271-6
pubmed: 10811594
J Clin Invest. 2012 Nov;122(11):3919-30
pubmed: 23023704
Diabetes. 2007 Jul;56(7):1834-41
pubmed: 17473225
Circ Res. 2000 Dec 8;87(12):1123-32
pubmed: 11110769
J Mol Cell Cardiol. 2015 Dec;89(Pt B):314-25
pubmed: 26456065
Circ Res. 2005 May 13;96(9):1006-13
pubmed: 15817886
Cell Metab. 2013 Aug 6;18(2):239-50
pubmed: 23931755
J Am Coll Cardiol. 2009 Nov 10;54(20):1891-8
pubmed: 19892241
Circ Res. 2015 Jul 31;117(4):346-51
pubmed: 26038571
Cell Calcium. 2014 Nov;56(5):372-80
pubmed: 25205537
Life Sci. 2013 Mar 28;92(11):601-8
pubmed: 23147391
Circulation. 2006 Aug 8;114(6):597-605
pubmed: 16894049
Diabetes. 2003 Feb;52(2):434-41
pubmed: 12540618
Biochim Biophys Acta. 2015 Feb;1852(2):209-18
pubmed: 24846717
Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H359-69
pubmed: 19060128
Diabetes. 2011 Jun;60(6):1770-8
pubmed: 21562078
Circulation. 2019 Apr 16;139(16):1913-1936
pubmed: 30646747
Circulation. 2016 Sep 20;134(12):883-94
pubmed: 27489254
Eur J Endocrinol. 2018 Apr;178(4):R127-R139
pubmed: 29440374
Antioxid Redox Signal. 2015 Jun 10;22(17):1545-62
pubmed: 25738230
Cell Mol Life Sci. 2014 Feb;71(4):549-74
pubmed: 23649149
Exp Cell Res. 2010 Oct 15;316(17):2903-9
pubmed: 20633551
Circ Res. 2011 May 13;108(10):1238-51
pubmed: 21474815
J Diabetes Investig. 2015 May;6(3):250-5
pubmed: 25969707
PPAR Res. 2016;2016:5938740
pubmed: 27446205
Cell Metab. 2016 Dec 13;24(6):795-806
pubmed: 28068222
Diabetes. 2013 Apr;62(4):1270-81
pubmed: 23223177
Diabetes Obes Metab. 2011 May;13(5):465-73
pubmed: 21272185
Cardiovasc Res. 1993 Oct;27(10):1800-9
pubmed: 8275527
Circ Res. 2018 Jan 5;122(1):58-73
pubmed: 29092894
PLoS One. 2013 Sep 24;8(9):e75927
pubmed: 24086665
JACC Heart Fail. 2013 Apr;1(2):115-22
pubmed: 24621836
J Clin Invest. 2002 Mar;109(6):817-26
pubmed: 11901190
J Am Coll Cardiol. 2006 Feb 21;47(4):693-700
pubmed: 16487830
J Biol Chem. 2013 Jun 21;288(25):18077-92
pubmed: 23658055
Can J Physiol Pharmacol. 2015 Jul;93(7):555-61
pubmed: 25996256
J Clin Invest. 2013 Dec;123(12):5319-33
pubmed: 24177427
Clin Exp Pharmacol Physiol. 2011 Aug;38(8):485-93
pubmed: 21554376
Cardiovasc Res. 2013 Aug 1;99(3):442-51
pubmed: 23708736
Am J Cardiol. 1972 Nov 8;30(6):595-602
pubmed: 4263660
Free Radic Biol Med. 2016 Aug;97:489-500
pubmed: 27393003
Nature. 2001 Dec 13;414(6865):813-20
pubmed: 11742414
Mol Biol Rep. 2012 Sep;39(9):8891-8
pubmed: 22707199
Diabetologia. 2004 Dec;47(12):2072-80
pubmed: 15662549
Circulation. 2000 Feb 29;101(8):899-907
pubmed: 10694530
Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1784-9
pubmed: 10677535
Circ Heart Fail. 2014 Mar 1;7(2):327-39
pubmed: 24389129
Front Physiol. 2018 Oct 30;9:1514
pubmed: 30425649
Diabetes. 2006 Mar;55(3):798-805
pubmed: 16505246
J Mol Cell Biol. 2013 Feb;5(1):61-3
pubmed: 23258696
Am J Physiol Cell Physiol. 2000 Feb;278(2):C423-35
pubmed: 10666039
J Mol Cell Cardiol. 2008 Sep;45(3):385-93
pubmed: 18657544
Life Sci. 2007 Feb 20;80(11):1051-6
pubmed: 17174344
Cardiovasc Drugs Ther. 2008 Apr;22(2):91-5
pubmed: 18247112
Annu Rev Physiol. 2010;72:81-94
pubmed: 20148668
Am J Physiol Regul Integr Comp Physiol. 2009 Oct;297(4):R1095-102
pubmed: 19657095
Free Radic Biol Med. 2016 Jan;90:12-23
pubmed: 26577173
Diabetes. 2004 May;53(5):1336-43
pubmed: 15111504
Biochim Biophys Acta. 2015 Feb;1852(2):252-61
pubmed: 24882754
Eur Heart J. 2016 Feb 7;37(6):572-6
pubmed: 26553540
Circ Res. 2009 Jan 30;104(2):170-8, 6p following 178
pubmed: 19096030
Autophagy. 2012 Apr;8(4):577-92
pubmed: 22498478
Cell Death Dis. 2014 Oct 23;5:e1479
pubmed: 25341033
Eur Heart J. 2015 Jul 14;36(27):1718-27, 1727a-1727c
pubmed: 25888006
Diabetes. 2009 Oct;58(10):2386-95
pubmed: 19592621
Circulation. 2014 Aug 12;130(7):554-64
pubmed: 24928681
Redox Biol. 2019 Feb;21:101100
pubmed: 30641298
Diabetes. 2002 Jun;51(6):1938-48
pubmed: 12031984
Am Heart J. 2005 Feb;149(2):349-54
pubmed: 15846276
Cell Rep. 2015 Mar 10;10(9):1521-1533
pubmed: 25753418
Hum Mol Genet. 2010 Mar 15;19(6):1066-75
pubmed: 20051426
J Mol Cell Cardiol. 2014 Aug;73:34-42
pubmed: 24412580
Cardiovasc Res. 2015 Sep 1;107(4):453-65
pubmed: 26101264
Circulation. 2006 Jun 6;113(22):2579-88
pubmed: 16735673
FASEB J. 2005 Dec;19(14):2057-9
pubmed: 16129698
Circ Res. 2015 Jan 16;116(2):279-88
pubmed: 25362209
JACC Heart Fail. 2015 Mar;3(3):202-11
pubmed: 25650370
Vasc Health Risk Manag. 2008;4(3):575-96
pubmed: 18827908
Front Physiol. 2012 Jul 19;3:292
pubmed: 22934044
Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H153-62
pubmed: 19429815
Am J Physiol Cell Physiol. 2014 May 1;306(9):C794-804
pubmed: 24553187
Biochim Biophys Acta. 2015 Feb;1852(2):232-42
pubmed: 24997452
Exp Cell Res. 2018 Dec 15;373(1-2):112-118
pubmed: 30359575
J Thorac Cardiovasc Surg. 2007 Jul;134(1):124-31, 131.e1-3
pubmed: 17599497
Br J Pharmacol. 2014 Apr;171(8):2080-90
pubmed: 24147975
Nat Commun. 2018 Mar 29;9(1):1286
pubmed: 29599478
Biochim Biophys Acta Mol Basis Dis. 2017 Aug;1863(8):1973-1983
pubmed: 27794418
Circ J. 2014;78(2):300-6
pubmed: 24334638
Front Biosci (Landmark Ed). 2009 Jun 01;14:5118-33
pubmed: 19482608
Biochim Biophys Acta. 2013 Aug;1832(8):1136-48
pubmed: 23524376
J Biol Chem. 2013 Dec 6;288(49):35372-86
pubmed: 24151077
Nutrients. 2012 Feb;4(2):78-90
pubmed: 22413063
J Biol Chem. 2007 Apr 27;282(17):12363-7
pubmed: 17344217
Basic Res Cardiol. 2008 Jul;103(4):319-27
pubmed: 18347835
J Clin Invest. 2012 Mar;122(3):1109-18
pubmed: 22326951
J Biol Chem. 2012 Aug 24;287(35):30024-34
pubmed: 22745122
Diabetologia. 2015 Aug;58(8):1949-58
pubmed: 25994075
Diabetes. 2006 Mar;55(3):608-15
pubmed: 16505222
Diabetes. 2009 Nov;58(11):2536-46
pubmed: 19690060
Cardiovasc Res. 2010 Nov 1;88(2):229-40
pubmed: 20639213
Am J Cardiol. 2004 Apr 1;93(7):870-5
pubmed: 15050491
Diabetes. 2004 Feb;53(2):463-73
pubmed: 14747299
Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2111-6
pubmed: 18256189
J Transl Med. 2010 Dec 15;8:133
pubmed: 21159162
Diabetes. 2007 Mar;56(3):641-6
pubmed: 17327431
Cardiovasc Diabetol. 2015 Aug 07;14:99
pubmed: 26245924
Clin Sci (Lond). 2008 Feb;114(3):195-210
pubmed: 18184113
Life Sci. 2016 Nov 1;164:42-51
pubmed: 27590611
J Cell Mol Med. 2009 Aug;13(8B):2330-41
pubmed: 19175688
Diabetologia. 2010 Aug;53(8):1783-94
pubmed: 20461356
Am J Physiol Regul Integr Comp Physiol. 2011 Jun;300(6):R1296-302
pubmed: 21346246
Physiol Rev. 2007 Jan;87(1):315-424
pubmed: 17237348
Am J Physiol Regul Integr Comp Physiol. 2007 Nov;293(5):R1787-97
pubmed: 17761517
PLoS One. 2014 Aug 19;9(8):e104771
pubmed: 25136835
Circ Res. 2019 Jan 4;124(1):121-141
pubmed: 30605420
Proteomics Clin Appl. 2016 Jan;10(1):25-38
pubmed: 26140508
Diabetes. 2016 Jan;65(1):255-68
pubmed: 26470784
Biochim Biophys Acta. 2016 Oct;1861(10):1555-68
pubmed: 26899197
Horm Metab Res. 1988 Jul;20(7):381-6
pubmed: 3169680
Circulation. 2005 Nov 22;112(21):3280-8
pubmed: 16301359
J Am Coll Cardiol. 2012 Feb 21;59(8):739-47
pubmed: 22340266
Basic Res Cardiol. 2015;110(4):36
pubmed: 25962702
Cell Metab. 2011 Oct 5;14(4):528-36
pubmed: 21982712
Nature. 2013 Oct 17;502(7471):372-6
pubmed: 24077098
Free Radic Biol Med. 2006 Mar 1;40(5):886-96
pubmed: 16520240
Life Sci. 2013 Mar 28;92(11):633-8
pubmed: 22484413
FASEB J. 2005 Jul;19(9):1088-95
pubmed: 15985532
J Clin Pathol. 1993 Jan;46(1):32-6
pubmed: 7679418
Rev Invest Clin. 2007 Mar-Apr;59(2):103-7
pubmed: 17633796
Circ Res. 2019 Apr 26;124(9):1360-1371
pubmed: 30786833
PLoS One. 2014 Mar 24;9(3):e93145
pubmed: 24664319