A Liver Biopsy Validation Pilot Study of Shear Wave Elastography, APRI, FIB-4, and Novel Serum Biomarkers for Liver Fibrosis Staging in Children With Chronic Viral Hepatitis.
APRI
MCP-1
Shear wave elastography
hepatitis B
hepatitis C
liver stiffness
pediatric chronic viral hepatitis
sFas
Journal
Global pediatric health
ISSN: 2333-794X
Titre abrégé: Glob Pediatr Health
Pays: United States
ID NLM: 101670224
Informations de publication
Date de publication:
2020
2020
Historique:
received:
07
01
2020
revised:
12
03
2020
accepted:
26
05
2020
entrez:
22
8
2020
pubmed:
22
8
2020
medline:
22
8
2020
Statut:
epublish
Résumé
As liver biopsy in children poses inherent risks, noninvasive measures of liver fibrosis are needed. This was a cross-sectional, liver biopsy validation pilot study of 16 participants evaluating the ability of shear wave elastography, aspartate transaminase to platelet ratio index (APRI), fibrosis index based on the 4 factors, and novel serum biomarkers to stage liver fibrosis in children with chronic hepatitis B or C. There was very high intrasegmental shear wave speed variation in our participants and little correlation with fibrosis. APRI and monocyte chemoattractant protein (MCP-1) were higher in fibrosis stage F2-3 versus F0-1 (
Identifiants
pubmed: 32821773
doi: 10.1177/2333794X20938931
pii: 10.1177_2333794X20938931
pmc: PMC7412911
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2333794X20938931Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Références
J Gastroenterol Hepatol. 2006 Oct;21 Suppl 3:S84-7
pubmed: 16958681
J Ultrasound Med. 2017 Feb;36(2):285-293
pubmed: 28039877
Tunis Med. 2005 Jul;83(7):400-3
pubmed: 16220696
Pediatrics. 2009 Nov;124(5):e1007-13
pubmed: 19805457
Gene Ther. 2008 Nov;15(21):1424-35
pubmed: 18509379
Gut. 2007 May;56(5):736-7
pubmed: 17440193
Oncotarget. 2017 Jul 11;8(28):45768-45776
pubmed: 28514753
Radiology. 2015 Mar;274(3):888-96
pubmed: 25393946
J Pediatr Gastroenterol Nutr. 2004 Nov;39(5):540-4
pubmed: 15572896
Gastroenterology. 2003 Oct;125(4):1085-93
pubmed: 14517792
Transl Res. 2010 Oct;156(4):229-34
pubmed: 20875899
Expert Rev Gastroenterol Hepatol. 2008 Aug;2(4):541-52
pubmed: 19072402
J Pediatr Surg. 2005 Aug;40(8):1366-7
pubmed: 16080952
Hepatology. 2008 Mar;47(3):836-43
pubmed: 18167062
J Hepatol. 2004 Oct;41(4):576-83
pubmed: 15464237
Pediatr Clin North Am. 2017 Jun;64(3):641-658
pubmed: 28502443
J Pediatr Gastroenterol Nutr. 2010 Mar;50(3):344-6
pubmed: 20118806
Cold Spring Harb Perspect Med. 2015 May 01;5(5):a021410
pubmed: 25934461
J Hepatol. 2007 Oct;47(4):598-607
pubmed: 17692984
J Pediatr Gastroenterol Nutr. 1998 Nov;27(5):603-5
pubmed: 9822332
J Pediatr Surg. 2013 Apr;48(4):789-95
pubmed: 23583135
J Hepatol. 1998 Oct;29(4):517-23
pubmed: 9824259
Ultrasonography. 2019 Oct;38(4):345-354
pubmed: 31500403
World J Gastroenterol. 2016 Apr 28;22(16):4238-49
pubmed: 27122674
J Viral Hepat. 2018 May;25(5):581-589
pubmed: 29230907
Hepatology. 2011 Mar;53(3):726-36
pubmed: 21319189
N Engl J Med. 2008 Oct 2;359(14):1486-500
pubmed: 18832247
Hepatology. 2015 Nov;62(5):1576-83
pubmed: 26223427
Dig Liver Dis. 2010 Jul;42 Suppl 3:S206-14
pubmed: 20547305
J Infect Dis. 2018 Apr 11;217(9):1408-1416
pubmed: 29390144
J Hepatol. 2006 Oct;45(4):529-38
pubmed: 16879891
Ann Transl Med. 2017 Feb;5(3):37
pubmed: 28251116
Ann Hepatol. 2018 Jun 4;17(4):592-595
pubmed: 29893700
J Pediatr Gastroenterol Nutr. 2012 Jul;55(1):82-7
pubmed: 22249806
Liver Int. 2008 Dec;28(10):1446-57
pubmed: 18466260
Gut. 2012 Mar;61(3):416-26
pubmed: 21813474
PLoS One. 2011;6(6):e21381
pubmed: 21731723
Eur Radiol. 2015 Nov;25(11):3214-21
pubmed: 25903706
Hepat Mon. 2010 Summer;10(3):168-72
pubmed: 22308134
Hepatol Res. 2009 Jul;39(7):675-84
pubmed: 19261000
Scand J Gastroenterol. 2014 Sep;49(9):1103-10
pubmed: 25048331
Hepatol Commun. 2017 Mar 23;1(2):87-98
pubmed: 29404447
J Ultrasound Med. 2014 Feb;33(2):197-203
pubmed: 24449721
Hepatology. 2012 Dec;56(6):2125-33
pubmed: 22767302
Radiology. 2015 Sep;276(3):845-61
pubmed: 26079489
Dig Liver Dis. 2012 Sep;44(9):780-7
pubmed: 22652148
J Pediatr Gastroenterol Nutr. 2017 Apr;64(4):512-517
pubmed: 27540711
J Clin Virol. 2005 Sep;34(1):63-70
pubmed: 16087126
J Clin Pharmacol. 2004 Jan;44(1):20-9
pubmed: 14681338
J Pediatr. 1986 Feb;108(2):224-7
pubmed: 3944707
Braz J Infect Dis. 2010 Jul-Aug;14(4):335-41
pubmed: 20963316
J Dig Dis. 2009 Feb;10(1):7-14
pubmed: 19236541
J Med Virol. 2004 Jun;73(2):244-9
pubmed: 15122799
J Pediatr Gastroenterol Nutr. 2006 Jan;42(1):93-9
pubmed: 16385261
BMC Gastroenterol. 2012 Feb 14;12:14
pubmed: 22333407
N Engl J Med. 2001 Feb 8;344(6):452-4
pubmed: 11172184
J Hepatol. 2007 Feb;46(2):230-8
pubmed: 17125873
Ultrasound Med Biol. 2013 Nov;39(11):1933-41
pubmed: 23932281
World J Gastroenterol. 2003 Nov;9(11):2490-6
pubmed: 14606082