Effects of dietary restriction on gut microbiota and CNS autoimmunity.
Journal
Clinical immunology (Orlando, Fla.)
ISSN: 1521-7035
Titre abrégé: Clin Immunol
Pays: United States
ID NLM: 100883537
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
29
12
2019
revised:
12
05
2020
accepted:
14
08
2020
pubmed:
22
8
2020
medline:
24
2
2022
entrez:
22
8
2020
Statut:
ppublish
Résumé
Multiple sclerosis (MS) is the most common central nervous system (CNS) autoimmune disease. It is due to the interplay of genetic and environmental factors. Current opinion is that diet could play a pathogenic role in disease onset and development. Dietary restriction (DR) without malnutrition markedly improves health and increases lifespan in multiple model organisms. DR regimens that utilize continuous or intermittent food restriction can induce anti-inflammatory, immuno-modulatory and neuroendocrine adaptations promoting health. These adaptations exert neuroprotective effects in the main MS animal model, experimental autoimmune encephalomyelitis (EAE). This review summarizes the current knowledge on DR-induced changes in gut microbial composition and metabolite production and its impact on underlying functional mechanisms. Studies demonstrating the protective effects of DR regimens on EAE and people with MS are also presented. This is a rapidly developing research field with important clinical implications for personalized dietary interventions in MS prevention and treatment.
Identifiants
pubmed: 32822833
pii: S1521-6616(20)30735-X
doi: 10.1016/j.clim.2020.108575
pmc: PMC7889763
mid: NIHMS1631978
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
108575Subventions
Organisme : NINDS NIH HHS
ID : R01 NS102633
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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