Human immunodeficiency virus and intraocular inflammation in the era of highly active anti retroviral therapy - An update.
AIDS
CMV retinitis
HAART
HIV
IRU
drug-induced uveitis
herpes zoster
intraocular inflammation
ocular TB
ocular opportunistic infections
ocular syphilis
ocular toxoplasmosis
retinopathy
uveitis
Journal
Indian journal of ophthalmology
ISSN: 1998-3689
Titre abrégé: Indian J Ophthalmol
Pays: India
ID NLM: 0405376
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
entrez:
23
8
2020
pubmed:
23
8
2020
medline:
15
5
2021
Statut:
ppublish
Résumé
Intraocular inflammation in patients with human immunodeficiency virus (HIV) infection is commonly due to infectious uveitis. Ocular lesions due to opportunistic infections (OI) are the most common and have been described extensively in the pre highly active antiretroviral therapy (HAART) era. Many eye lesions were classified as acquired immunodeficiency syndrome (AIDS) defining illnesses. HAART-associated improvement in immunity of the individual has changed the pattern of incidence of these hitherto reported known lesions leading to a marked reduction in the occurrence of ocular OI. Newer ocular lesions and newer ocular manifestations of known agents have been noted. Immune recovery uveitis (IRU), the new menace, which occurs as part of immune recovery inflammatory syndrome (IRIS) in the eye, can present with significant ocular inflammation and can pose a diagnostic and therapeutic challenge. Balancing the treatment of inflammation with the risk of reactivation of OI is a task by itself. Ocular involvement in the HAART era can be due to the adverse effects of some systemic drugs used in the management of HIV/AIDS. Drug-associated retinal toxicity and other ocular side effects are being increasingly reported. In this review, we discuss the ocular manifestations in HIV patients and its varied presentations following the introduction of HAART, drug-associated lesions, and the current treatment guidelines.
Identifiants
pubmed: 32823395
pii: IndianJOphthalmol_2020_68_9_1787_292514
doi: 10.4103/ijo.IJO_1248_20
pmc: PMC7690468
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1787-1798Déclaration de conflit d'intérêts
None
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