Miliary microaneurysms: An angiographic biomarker of leukemic retinopathy?
CML
fluorescein angiography
leukemia
leukemic retinopathy
miliary microaneurysm
Journal
Indian journal of ophthalmology
ISSN: 1998-3689
Titre abrégé: Indian J Ophthalmol
Pays: India
ID NLM: 0405376
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
entrez:
23
8
2020
pubmed:
23
8
2020
medline:
15
5
2021
Statut:
ppublish
Résumé
A 16-year-old girl was referred as retinitis and vasculitis post-typhoid fever. Fundus examination revealed bilateral pseudo-sheathing, scattered hemorrhages with retinal infiltrates. Wide-field fundus fluorescein angiography (FFA) showed peripheral vascular hyperfluorescence; 55° FFA images showed a "firecracker-like" peripheral vasculature, but a closer look revealed miliary microaneurysms (MAs). Peripheral smear examination clinched the diagnosis of chronic myeloid leukemia. MAs on FFA in leukemic retinopathy have been frequently described in the literature. Our report emphasizes its presence, miliary nature, and need for closer inspection of FFA images. We believe that this angiographic sign has potential to become one of the imaging biomarkers of leukemic retinopathy.
Identifiants
pubmed: 32823464
pii: IndianJOphthalmol_2020_68_9_2017_292557
doi: 10.4103/ijo.IJO_2375_19
pmc: PMC7690553
doi:
Substances chimiques
Biomarkers
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
2017-2019Déclaration de conflit d'intérêts
None
Références
Can J Ophthalmol. 2014 Jun;49(3):e68-70
pubmed: 24862787
Indian J Ophthalmol. 2019 Dec;67(12):2049-2051
pubmed: 31755450
Ocul Immunol Inflamm. 2019;27(4):571-577
pubmed: 29370564
Am J Ophthalmol. 1975 Aug;80(2):242-8
pubmed: 1057377
Exp Ther Med. 2016 Oct;12(4):2253-2256
pubmed: 27703497