The Role of Atypical Cannabinoid Ligands O-1602 and O-1918 on Skeletal Muscle Homeostasis with a Focus on Obesity.
Adaptor Proteins, Signal Transducing
/ genetics
Adult
Animals
Anisoles
/ pharmacology
Cannabidiol
/ analogs & derivatives
Cell Line
Cells, Cultured
Cyclohexanes
/ pharmacology
Fatty Acids
/ metabolism
Female
Homeostasis
Humans
Male
Mice
Middle Aged
Muscle, Skeletal
/ drug effects
NFATC Transcription Factors
/ genetics
Obesity
/ metabolism
PPAR gamma
/ genetics
Pyruvate Dehydrogenase Acetyl-Transferring Kinase
/ genetics
Rats
Rats, Sprague-Dawley
Receptors, G-Protein-Coupled
/ genetics
Atypical Cannabinoids
GPR18
O-1602
O-1918
obesity and skeletal muscle
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
18 Aug 2020
18 Aug 2020
Historique:
received:
18
06
2020
revised:
28
07
2020
accepted:
13
08
2020
entrez:
23
8
2020
pubmed:
23
8
2020
medline:
17
2
2021
Statut:
epublish
Résumé
O-1602 and O-1918 are atypical cannabinoid ligands for GPR55 and GPR18, which may be novel pharmaceuticals for the treatment of obesity by targeting energy homeostasis regulation in skeletal muscle. This study aimed to determine the effect of O-1602 or O-1918 on markers of oxidative capacity and fatty acid metabolism in the skeletal muscle. Diet-induced obese (DIO) male Sprague Dawley rats were administered a daily intraperitoneal injection of O-1602, O-1918 or vehicle for 6 weeks. C
Identifiants
pubmed: 32824681
pii: ijms21165922
doi: 10.3390/ijms21165922
pmc: PMC7460607
pii:
doi:
Substances chimiques
1,3-dimethoxy-5-methyl-2-(3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl)benzene
0
APPL2 protein, human
0
Adaptor Proteins, Signal Transducing
0
Anisoles
0
Cyclohexanes
0
Fatty Acids
0
GPR18 protein, human
0
NFATC Transcription Factors
0
NFATC1 protein, human
0
PDK4 protein, human
0
PPAR gamma
0
Pyruvate Dehydrogenase Acetyl-Transferring Kinase
0
Receptors, G-Protein-Coupled
0
Cannabidiol
19GBJ60SN5
O-1602 compound
317321-41-8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Allen Foundation
ID : Project ID 2011.385
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