Mitochondrial Potassium Channels as Druggable Targets.
ATP
ROS
calcium
mitochondria
potassium channel openers
potassium channels
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
18 08 2020
18 08 2020
Historique:
received:
24
06
2020
revised:
03
08
2020
accepted:
13
08
2020
entrez:
23
8
2020
pubmed:
23
8
2020
medline:
16
6
2021
Statut:
epublish
Résumé
Mitochondrial potassium channels have been described as important factors in cell pro-life and death phenomena. The activation of mitochondrial potassium channels, such as ATP-regulated or calcium-activated large conductance potassium channels, may have cytoprotective effects in cardiac or neuronal tissue. It has also been shown that inhibition of the mitochondrial Kv1.3 channel may lead to cancer cell death. Hence, in this paper, we examine the concept of the druggability of mitochondrial potassium channels. To what extent are mitochondrial potassium channels an important, novel, and promising drug target in various organs and tissues? The druggability of mitochondrial potassium channels will be discussed within the context of channel molecular identity, the specificity of potassium channel openers and inhibitors, and the unique regulatory properties of mitochondrial potassium channels. Future prospects of the druggability concept of mitochondrial potassium channels will be evaluated in this paper.
Identifiants
pubmed: 32824877
pii: biom10081200
doi: 10.3390/biom10081200
pmc: PMC7466137
pii:
doi:
Substances chimiques
Potassium Channels
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Narodowe Centrum Nauki
ID : 2016/21/B/NZ1/02769
Pays : International
Organisme : Narodowe Centrum Nauki
ID : 2019/34/A/NZ1/00352
Pays : International
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