Intramuscular Mechanisms Mediating Adaptation to Low-Carbohydrate, High-Fat Diets during Exercise Training.
Adaptation, Physiological
/ physiology
Biological Transport
Diet, Carbohydrate-Restricted
Diet, High-Fat
Dietary Carbohydrates
/ metabolism
Dietary Fats
/ metabolism
Energy Metabolism
Exercise
/ physiology
Fatty Acids, Nonesterified
/ blood
Glucose
/ metabolism
Glycogen
/ metabolism
Humans
Muscle Proteins
/ metabolism
Muscle, Skeletal
/ metabolism
Oxidation-Reduction
Sports Nutritional Physiological Phenomena
/ physiology
Triglycerides
/ metabolism
CPT-1
PDH activity
fat adaptation
fat oxidation
substrate utilization
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
19 Aug 2020
19 Aug 2020
Historique:
received:
30
07
2020
revised:
15
08
2020
accepted:
17
08
2020
entrez:
23
8
2020
pubmed:
23
8
2020
medline:
30
3
2021
Statut:
epublish
Résumé
Interest in low-carbohydrate, high-fat (LCHF) diets has increased over recent decades given the theorized benefit of associated intramuscular adaptations and shifts in fuel utilization on endurance exercise performance. Consuming a LCHF diet during exercise training increases the availability of fat (i.e., intramuscular triglyceride stores; plasma free fatty acids) and decreases muscle glycogen stores. These changes in substrate availability increase reliance on fat oxidation for energy production while simultaneously decreasing reliance on carbohydrate oxidation for fuel during submaximal exercise. LCHF diet-mediated changes in substrate oxidation remain even after endogenous or exogenous carbohydrate availability is increased, suggesting that the adaptive response driving changes in fat and carbohydrate oxidation lies within the muscle and persists even when the macronutrient content of the diet is altered. This narrative review explores the intramuscular adaptations underlying increases in fat oxidation and decreases in carbohydrate oxidation with LCHF feeding. The possible effects of LCHF diets on protein metabolism and post-exercise muscle remodeling are also considered.
Identifiants
pubmed: 32824957
pii: nu12092496
doi: 10.3390/nu12092496
pmc: PMC7551624
pii:
doi:
Substances chimiques
Dietary Carbohydrates
0
Dietary Fats
0
Fatty Acids, Nonesterified
0
Muscle Proteins
0
Triglycerides
0
Glycogen
9005-79-2
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Oak Ridge Institute for Science and Education
ID : n/a
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