Polymorphisms Involved in Response to Biological Agents Used in Rheumatoid Arthritis.
CD20
CD80
CD86
IL-1
IL-6
TNF-α
polymorphism
rheumatoid arthritis
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
19 08 2020
19 08 2020
Historique:
received:
06
07
2020
revised:
11
08
2020
accepted:
15
08
2020
entrez:
23
8
2020
pubmed:
23
8
2020
medline:
7
9
2021
Statut:
epublish
Résumé
Rheumatoid arthritis (RA) is a systemic disease that leads to joint destruction. During the last decade, the therapy of RA has been principally based on biological drugs. Although the efficacy of biological therapy has been established, patients demonstrated a high heterogeneity in clinical response to treatment. Several genetic polymorphisms play a part in the different response to biological drugs. This review summarizes the pharmacogenetics of biological agents approved for clinical RA treatment. We reviewed PubMed papers published over the past 20 years (2000-2020), inserting as the search term "rheumatoid arthritis and polymorphisms". Despite some studies showing important correlations between genetic polymorphisms and response to biological therapy in RA patients, most of these findings are still lacking and inconsistent. The personalized treatment according to a pharmacogenetics approach is promising but the available pharmacogenetics data on biological treatment in RA are not adequate and reliable to recommend pharmacogenetic tests before starting biological therapy in RA patients.
Identifiants
pubmed: 32825059
pii: biom10091203
doi: 10.3390/biom10091203
pmc: PMC7565539
pii:
doi:
Substances chimiques
Biological Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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