Evaluation of Myocardial Gene Expression Profiling for Superior Diagnosis of Idiopathic Giant-Cell Myocarditis and Clinical Feasibility in a Large Cohort of Patients with Acute Cardiac Decompensation.

endomyocardial biopsy gene-expression profiling idiopathic giant-cell myocarditis

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
19 Aug 2020
Historique:
received: 19 07 2020
revised: 10 08 2020
accepted: 12 08 2020
entrez: 23 8 2020
pubmed: 23 8 2020
medline: 23 8 2020
Statut: epublish

Résumé

The diagnostic approach to idiopathic giant-cell myocarditis (IGCM) is based on identifying various patterns of inflammatory cell infiltration and multinucleated giant cells (GCs) in histologic sections taken from endomyocardial biopsies (EMBs). The sampling error for detecting focally located GCs by histopathology is high, however. The aim of this study was to demonstrate the feasibility of gene profiling as a new diagnostic method in clinical practice, namely in a large cohort of patients suffering from acute cardiac decompensation.

Identifiants

pubmed: 32825201
pii: jcm9092689
doi: 10.3390/jcm9092689
pmc: PMC7563288
pii:
doi:

Types de publication

Journal Article

Langues

eng

Déclaration de conflit d'intérêts

None declared.

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Auteurs

Felicitas Escher (F)

Institute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany.
Department of Cardiology, Charité-University Medicine Berlin, Campus Virchow-Klinikum, 13353 Berlin, Germany.
German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany.

Heiko Pietsch (H)

Institute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany.
Department of Cardiology, Charité-University Medicine Berlin, Campus Virchow-Klinikum, 13353 Berlin, Germany.
German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany.

Ganna Aleshcheva (G)

Institute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany.

Philip Wenzel (P)

University Medical Center Mainz, Department of Cardiology and Center for Thrombosis and Haemostasis, 55131 Mainz, Germany.

Friedrich Fruhwald (F)

Department of Internal Medicine, Division of Cardiology, Medical University Graz, 8036 Graz, Austria.

Christian Stumpf (C)

Department of Cardiology, Klinikum Bayreuth GmbH, Medical Clinic II, 95445 Bayreuth, Germany.

Dirk Westermann (D)

University Heart Center Hamburg, Department of Internal Medicine and Interventional Cardiology, 20251 Hamburg, Germany.

Johann Bauersachs (J)

Department of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.

Frank Enseleit (F)

Department of Cardiology, University Hospital Zurich, 8091 Zurich, Switzerland.

Frank Ruschitzka (F)

Department of Cardiology, University Hospital Zurich, 8091 Zurich, Switzerland.

Herbert Nägele (H)

Department for Cardiac Insufficiency and Device Therapy, Albertinen-Hospital, 22457 Hamburg, Germany.

Karl-Ludwig Laugwitz (KL)

Department of Cardiology, Klinikum rechts der Isar, 81675 Munich, Germany.

Hendrik Haake (H)

Department of Cardiology, Electrophysiology and Intensive Care Medicine, Kliniken Maria Hilf GmbH, 41063 Monchengladbach, Germany.

Norbert Frey (N)

Department of Internal Medicine III-Cardiology, Angiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, 24105 Kiel, Germany.

Johannes Brachmann (J)

Department of Internal Medicine, Division of Cardiology, Clinical Center Coburg, 96450 Coburg, Germany.

Kurt Huber (K)

3rd Medical Department with Cardiology, Wilhelminenhospital Vienna, 1160 Vienna, Austria.

Rüdiger Christian Braun-Dullaeus (RC)

Department of Cardiology und Angiology, University Magdeburg, 39106 Magdeburg, Germany.

Martin W Bergmann (MW)

Cardiologicum Hamburg Wandsbek, 22041 Hamburg, Germany.

Jörg Strotmann (J)

Department of Cardiology, Städtisches Krankenhaus Kiel GmbH, 24116 Kiel, Germany.

Gerian Grönefeld (G)

Department of Cardiology, Asklepios Klinik Barmbek, 22307 Hamburg, Germany.

Jürgen Krülls-Münch (J)

Department of Cardiology and Angiology, Carl-Thiem-Klinikum Cottbus gGmbH, 03048 Cottbus, Germany.

Ralf Westenfeld (R)

Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich-Heine University, 40225 Düsseldorf, Germany.

Carsten Skurk (C)

German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany.
Department of Cardiology Charité-University Medicine Berlin, Campus Benjamin Franklin, 12203 Berlin, Germany.

Ulf Landmesser (U)

German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany.
Department of Cardiology Charité-University Medicine Berlin, Campus Benjamin Franklin, 12203 Berlin, Germany.

Burkert Pieske (B)

Department of Cardiology, Charité-University Medicine Berlin, Campus Virchow-Klinikum, 13353 Berlin, Germany.
German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany.

Ulrich M Gross (UM)

Institute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany.

Lars Morawietz (L)

Institute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany.

Heinz-Peter Schultheiss (HP)

Institute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany.

Classifications MeSH