Identification of microRNAs Targeting the Transporter Associated with Antigen Processing TAP1 in Melanoma.
immune escape
melanoma
microRNA
transporter associated with antigen processing
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
20 Aug 2020
20 Aug 2020
Historique:
received:
29
06
2020
revised:
12
08
2020
accepted:
14
08
2020
entrez:
23
8
2020
pubmed:
23
8
2020
medline:
23
8
2020
Statut:
epublish
Résumé
The underlying molecular mechanisms of the aberrant expression of components of the HLA class I antigen processing and presentation machinery (APM) in tumors leading to evasion from T cell-mediated immune surveillance could be due to posttranscriptional regulation mediated by microRNAs (miRs). So far, some miRs controlling the expression of different APM components have been identified. Using in silico analysis and an miR enrichment protocol in combination with small RNA sequencing, miR-26b-5p and miR-21-3p were postulated to target the 3' untranslated region (UTR) of the peptide transporter TAP1, which was confirmed by high free binding energy and dual luciferase reporter assays. Overexpression of miR-26b-5p and miR-21-3p in melanoma cells downregulated the TAP1 protein and reduced expression of HLA class I cell surface antigens, which could be reverted by miR inhibitors. Moreover, miR-26b-5p overexpression induced a decreased T cell recognition. Furthermore, an inverse expression of miR-26b-5p and miR-21-3p with TAP1 was found in primary melanoma lesions, which was linked with the frequency of CD8
Identifiants
pubmed: 32825219
pii: jcm9092690
doi: 10.3390/jcm9092690
pmc: PMC7563967
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : 105533105
Organisme : Deutsche Forschungsgemeinschaft
ID : SE-581.22-1
Organisme : German-Israeli Foundation for Scientific Research and Development
ID : GIF I-37-4145.II-2016
Organisme : Dr. Mildred Scheel Stiftung für Krebsforschung
ID : 70113861
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