Dengue Virus Serotype 4 Is Responsible for the Outbreak of Dengue in East Java City of Jember, Indonesia.
Indonesia
Java
dengue
molecular epidemiology
serotype
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
20 08 2020
20 08 2020
Historique:
received:
29
06
2020
revised:
03
08
2020
accepted:
18
08
2020
entrez:
23
8
2020
pubmed:
23
8
2020
medline:
9
3
2021
Statut:
epublish
Résumé
Outbreaks of dengue virus (DENV) in Indonesia have been mainly caused by the DENV serotype-1; -2; or -3. The DENV-4 was the least-reported serotype in Indonesia during the last five decades. We recently conducted a molecular epidemiology study of dengue in the Jember regency, East Java province, Indonesia. Dengue is endemic in the region and outbreaks occur annually. We investigated the clinical characteristics and etiology of dengue-like febrile illness in this regency to understand the disease dynamics. A total of 191 patients with clinical symptoms similar to dengue were recruited during an 11-month study in 2019-2020. Children accounted for the majority of cases and dengue burden was estimated in 41.4% of the cases based on NS1 antigen, viral RNA, and IgG/IgM antibody detection with the majority (73.4%) being primary infections. Secondary infection was significantly associated with a higher risk of severe dengue manifestation. All four DENV serotypes were detected in Jember. Strikingly, we observed the predominance of DENV-4, followed by DENV-3, DENV-1, and DENV-2. Genotype determination using Envelope gene sequence revealed the classification into Genotype I, Cosmopolitan Genotype, Genotype I, and Genotype II for DENV-1, -2, -3, and -4, respectively. The predominance of DENV-4 in Jember may be associated with a new wave of DENV infections and spread in a non-immune population lacking a herd-immunity to this particular serotype.
Identifiants
pubmed: 32825262
pii: v12090913
doi: 10.3390/v12090913
pmc: PMC7551817
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Emerg Microbes Infect. 2017 May 10;6(5):e33
pubmed: 28487557
PLoS Negl Trop Dis. 2013 Aug 08;7(8):e2354
pubmed: 23951374
J Travel Med. 2018 Aug 1;25(1):
pubmed: 30113689
Infect Genet Evol. 2003 May;3(1):19-28
pubmed: 12797969
Virology. 2002 Nov 10;303(1):110-9
pubmed: 12482662
PLoS Negl Trop Dis. 2017 May 22;11(5):e0005483
pubmed: 28531223
Infect Genet Evol. 2014 Dec;28:48-54
pubmed: 25219342
J Trop Med. 2018 Feb 15;2018:8127093
pubmed: 29666658
BMC Infect Dis. 2016 Jul 08;16:320
pubmed: 27393011
PLoS Negl Trop Dis. 2013 Jul 25;7(7):e2331
pubmed: 23936565
Infect Genet Evol. 2012 Mar;12(2):309-14
pubmed: 22226705
PLoS Negl Trop Dis. 2013 Oct 24;7(10):e2483
pubmed: 24205417
Infect Genet Evol. 2009 Jul;9(4):523-40
pubmed: 19460319
Mol Biol Evol. 2018 Jun 1;35(6):1547-1549
pubmed: 29722887
Clin Microbiol Rev. 1990 Oct;3(4):376-96
pubmed: 2224837
PLoS Negl Trop Dis. 2019 Jul 29;13(7):e0007592
pubmed: 31356608
Arch Virol. 2013 Jul;158(7):1445-59
pubmed: 23471635
Infect Genet Evol. 2016 Jan;37:88-93
pubmed: 26553170
J Clin Microbiol. 1998 Jan;36(1):234-8
pubmed: 9431954
BMC Infect Dis. 2019 Mar 12;19(1):243
pubmed: 30866835
J Infect Dis. 2016 Oct 1;214(7):986-93
pubmed: 26984144
Infect Genet Evol. 2008 Mar;8(2):191-204
pubmed: 18243816
Nat Rev Microbiol. 2010 Dec;8(12 Suppl):S7-16
pubmed: 21079655
PLoS One. 2017 Jun 2;12(6):e0178443
pubmed: 28575000
J Gen Virol. 1994 Jan;75 ( Pt 1):65-75
pubmed: 8113741
Virus Genes. 2017 Dec;53(6):778-788
pubmed: 28600724
PLoS Comput Biol. 2019 Apr 8;15(4):e1006650
pubmed: 30958812
Southeast Asian J Trop Med Public Health. 1987 Sep;18(3):269-74
pubmed: 3433157
PLoS One. 2016 May 23;11(5):e0154760
pubmed: 27213782
PLoS Negl Trop Dis. 2019 Oct 21;13(10):e0007785
pubmed: 31634352
J Gen Virol. 1997 Sep;78 ( Pt 9):2279-84
pubmed: 9292015
Adv Virus Res. 2003;59:315-41
pubmed: 14696333
Am J Trop Med Hyg. 2015 May;92(5):999-1005
pubmed: 25825386
J Med Virol. 2003 Oct;71(2):259-64
pubmed: 12938201
J Virol Methods. 2008 Dec;154(1-2):175-81
pubmed: 18778736
Cell Rep. 2018 Oct 30;25(5):1214-1224
pubmed: 30380413
Clin Microbiol Rev. 1998 Jul;11(3):480-96
pubmed: 9665979
Virol J. 2019 Jul 25;16(1):93
pubmed: 31345242
Sci Rep. 2017 Apr 05;7:45505
pubmed: 28378782
Pathog Glob Health. 2016 May;110(3):119-29
pubmed: 27215933
Rev Med Virol. 2019 Jul;29(4):e2037
pubmed: 31099110
Southeast Asian J Trop Med Public Health. 2014 Jan;45(1):53-61
pubmed: 24964654
Infect Genet Evol. 2015 Jun;32:165-77
pubmed: 25784569
Virology. 2002 Jun 20;298(1):63-72
pubmed: 12093174
J Infect Dev Ctries. 2014 Jun 11;8(6):733-41
pubmed: 24916872
J Infect Public Health. 2018 Sep - Oct;11(5):617-625
pubmed: 29056517
PLoS Negl Trop Dis. 2016 Feb 05;10(2):e0004398
pubmed: 26848841
J Virol. 1998 Jan;72(1):73-83
pubmed: 9420202