Utility of Comprehensive Serum Glycopeptide Spectra Analysis (CSGSA) for the Detection of Early Stage Epithelial Ovarian Cancer.
cancer antigen 125
comprehensive serum glycopeptide spectra analysis
epithelial ovarian cancer
human epididymis protein 4
orthogonal partial least-squares discriminant analysis
screening
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
21 Aug 2020
21 Aug 2020
Historique:
received:
06
07
2020
revised:
12
08
2020
accepted:
18
08
2020
entrez:
23
8
2020
pubmed:
23
8
2020
medline:
23
8
2020
Statut:
epublish
Résumé
Comprehensive serum glycopeptide spectra analysis (CSGSA) evaluates >10,000 serum glycopeptides and identifies unique glycopeptide peaks and patterns via supervised orthogonal partial least-squares discriminant modeling. CSGSA was more accurate than cancer antigen 125 (CA125) or human epididymis protein 4 (HE4) for detecting early stage epithelial ovarian cancer. Combined CSGSA, CA125, and HE4 had improved diagnostic performance. Thus, CSGSA may be a useful screening tool for detecting early stage epithelial ovarian cancer.
Identifiants
pubmed: 32825727
pii: cancers12092374
doi: 10.3390/cancers12092374
pmc: PMC7563232
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : 17H04340;18K09274; and 18K09300
Organisme : AMED
ID : 20lm0203004j0003
Organisme : Ensign Endowment for Gynecologic Cancer Research
ID : -
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