MCLR induces dysregulation of calcium homeostasis and endoplasmic reticulum stress resulting in apoptosis in Sertoli cells.
Apoptosis
Calcium homeostasis
ER stress
MAPK
Sertoli cell
Journal
Chemosphere
ISSN: 1879-1298
Titre abrégé: Chemosphere
Pays: England
ID NLM: 0320657
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
09
05
2020
revised:
20
07
2020
accepted:
27
07
2020
pubmed:
23
8
2020
medline:
22
12
2020
entrez:
23
8
2020
Statut:
ppublish
Résumé
Microcystins-LR (MCLR) is a potent reproductive system toxin. We have previously shown that MCLR induced endoplasmic reticulum (ER) stress and apoptosis in testis. ER is the main calcium storage site in cells, and its calcium homeostasis plays an important role in the regulation of apoptosis. Hence, in the present study, we have investigated the role of calcium (Ca
Identifiants
pubmed: 32828052
pii: S0045-6535(20)32063-4
doi: 10.1016/j.chemosphere.2020.127868
pii:
doi:
Substances chimiques
Microcystins
0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
127868Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.