Uridine natural products: Challenging targets and inspiration for novel small molecule inhibitors.
Inhibitor discovery
Natural product antibiotics
Nucleoside analog
Structure-activity relationship
Uridine
Journal
Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298
Informations de publication
Date de publication:
15 09 2020
15 09 2020
Historique:
received:
18
06
2020
accepted:
18
07
2020
entrez:
24
8
2020
pubmed:
24
8
2020
medline:
16
6
2021
Statut:
ppublish
Résumé
Nucleoside derivatives, in particular those featuring uridine, are familiar components of the nucleoside family of bioactive natural products. The structural complexity and biological activities of these compounds have inspired research from organic chemistry and chemical biology communities seeking to develop novel approaches to assemble the challenging molecular targets, to gain inspiration for enzyme inhibitor development and to fuel antibiotic discovery efforts. This review will present recent case studies describing the total synthesis and biosynthesis of uridine natural products, and de novo synthetic efforts exploiting features of the natural products to produce simplified scaffolds. This research has culminated in the development of complementary strategies that can lead to effective uridine-based inhibitors and antibiotics. The strengths and challenges of the juxtaposing methods will be illustrated by examining select uridine natural products. Moreover, structure-activity relationships (SAR) for each natural product-inspired scaffold will be discussed, highlighting the impact on inhibitor development, with the aim of future uridine-based small molecule expansion.
Identifiants
pubmed: 32828427
pii: S0968-0896(20)30491-0
doi: 10.1016/j.bmc.2020.115661
pmc: PMC7446765
mid: NIHMS1615957
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Biological Products
0
Enzyme Inhibitors
0
Phosphates
0
Polyprenols
0
Uridine
WHI7HQ7H85
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
115661Subventions
Organisme : NIGMS NIH HHS
ID : F32 GM136023
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM131627
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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