Induction of potent cell growth inhibition by schizophyllan/K-ras antisense complex in combination with gemcitabine.
Amino Acid Sequence
Antineoplastic Agents
/ chemistry
Cell Cycle
/ drug effects
Cell Line, Tumor
Cells, Cultured
Deoxycytidine
/ analogs & derivatives
Drug Delivery Systems
Drug Liberation
Drug Therapy, Combination
Humans
Lectins, C-Type
/ genetics
Lung Neoplasms
/ drug therapy
Oligonucleotides, Antisense
/ chemistry
Sizofiran
/ chemistry
Gemcitabine
Antisense DNA
Drug delivery
Gemcitabine
K-ras
Schizophyllan
Journal
Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298
Informations de publication
Date de publication:
15 09 2020
15 09 2020
Historique:
received:
06
02
2020
revised:
20
07
2020
accepted:
24
07
2020
entrez:
24
8
2020
pubmed:
24
8
2020
medline:
16
6
2021
Statut:
ppublish
Résumé
Antisense oligonucleotides (AS-ODNs) specifically hybridize with target mRNAs, resulting in interference with the splicing mechanism or the regulation of protein translation. In our previous reports, we demonstrated that β-glucan schizophyllan (SPG) can form a complex with AS-ODNs attached with oligo deoxyadenosine dA
Identifiants
pubmed: 32828430
pii: S0968-0896(20)30498-3
doi: 10.1016/j.bmc.2020.115668
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Lectins, C-Type
0
Oligonucleotides, Antisense
0
dectin 1
0
Deoxycytidine
0W860991D6
Sizofiran
7F763NNC9X
Gemcitabine
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
115668Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.