Laser irradiated phenothiazines: New potential treatment for COVID-19 explored by molecular docking.
Antiviral Agents
/ chemistry
Betacoronavirus
/ drug effects
COVID-19
Coronavirus 3C Proteases
Coronavirus Infections
/ drug therapy
Cysteine Endopeptidases
/ chemistry
Host Microbial Interactions
/ drug effects
Humans
Lasers, Solid-State
Molecular Docking Simulation
Pandemics
Phenothiazines
/ chemistry
Photochemical Processes
Pneumonia, Viral
/ drug therapy
SARS-CoV-2
Structure-Activity Relationship
Viral Nonstructural Proteins
/ antagonists & inhibitors
COVID-19 Drug Treatment
COVID-19
Laser irradiated phenothiazines
Molecular docking
SARS-CoV-2
Journal
Journal of photochemistry and photobiology. B, Biology
ISSN: 1873-2682
Titre abrégé: J Photochem Photobiol B
Pays: Switzerland
ID NLM: 8804966
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
22
04
2020
revised:
03
07
2020
accepted:
12
08
2020
pubmed:
24
8
2020
medline:
25
9
2020
entrez:
24
8
2020
Statut:
ppublish
Résumé
The worldwide infection with the new Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) demands urgently new potent treatment(s). In this study we predict, using molecular docking, the binding affinity of 15 phenothiazines (antihistaminic and antipsychotic drugs) when interacting with the main protease (M
Identifiants
pubmed: 32829256
pii: S1011-1344(20)30447-4
doi: 10.1016/j.jphotobiol.2020.111997
pmc: PMC7428740
pii:
doi:
Substances chimiques
Antiviral Agents
0
Phenothiazines
0
Viral Nonstructural Proteins
0
Cysteine Endopeptidases
EC 3.4.22.-
Coronavirus 3C Proteases
EC 3.4.22.28
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111997Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors do not declare any conflict of interest.
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