Layer-Specific Inhibitory Microcircuits of Layer 6 Interneurons in Rat Prefrontal Cortex.

Action Potentials Animals Axons / physiology Cell Membrane / physiology Electrophysiological Phenomena GABAergic Neurons / physiology Image Processing, Computer-Assisted Interneurons / physiology Male Nerve Net / cytology Patch-Clamp Techniques Prefrontal Cortex / cytology Rats Rats, Wistar White Matter / cytology
axonal projection interneurons layer 6 medial prefrontal cortex

Journal

Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718

Informations de publication

Date de publication:
01 01 2021
Historique:
received: 23 01 2020
revised: 06 06 2020
accepted: 02 07 2020
pubmed: 24 8 2020
medline: 31 12 2021
entrez: 24 8 2020
Statut: ppublish

Résumé

GABAergic interneurons in different cortical areas play important roles in diverse higher-order cognitive functions. The heterogeneity of interneurons is well characterized in different sensory cortices, in particular in primary somatosensory and visual cortex. However, the structural and functional properties of the medial prefrontal cortex (mPFC) interneurons have received less attention. In this study, a cluster analysis based on axonal projection patterns revealed four distinct clusters of L6 interneurons in rat mPFC: Cluster 1 interneurons showed axonal projections similar to Martinotti-like cells extending to layer 1, cluster 2 displayed translaminar projections mostly to layer 5, and cluster 3 interneuron axons were confined to the layer 6, whereas those of cluster 4 interneurons extend also into the white matter. Correlations were found between neuron location and axonal distribution in all clusters. Moreover, all cluster 1 L6 interneurons showed a monotonically adapting firing pattern with an initial high-frequency burst. All cluster 2 interneurons were fast-spiking, while neurons in cluster 3 and 4 showed heterogeneous firing patterns. Our data suggest that L6 interneurons that have distinct morphological and physiological characteristics are likely to innervate different targets in mPFC and thus play differential roles in the L6 microcircuitry and in mPFC-associated functions.

Identifiants

DOI: 10.1093/cercor/bhaa201 PMID: 32829414 PMC: PMC7727376
pubmed: 32829414
pii: 5895439
doi: 10.1093/cercor/bhaa201
pmc: PMC7727376
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

32-47

Informations de copyright

© The Author(s) 2020. Published by Oxford University Press.

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Auteurs

Chao Ding (C)

Institute of Neuroscience and Medicine, INM-10 Function of Cortical Microcircuits Group, Research Centre Jülich, 52425 Jülich, Germany.

Vishalini Emmenegger (V)

Institute of Neuroscience and Medicine, INM-10 Function of Cortical Microcircuits Group, Research Centre Jülich, 52425 Jülich, Germany.
Department of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.

Kim Schaffrath (K)

Institute of Neuroscience and Medicine, INM-10 Function of Cortical Microcircuits Group, Research Centre Jülich, 52425 Jülich, Germany.
Department of Ophthalmology, RWTH Aachen University Hospital, Medical School, 52074 Aachen, Germany.

Dirk Feldmeyer (D)

Institute of Neuroscience and Medicine, INM-10 Function of Cortical Microcircuits Group, Research Centre Jülich, 52425 Jülich, Germany.
Department of Psychiatry, Psychotherapy and Psychosomatics, Medical School, RWTH Aachen University Hospital, 52074 Aachen, Germany.
JARA-Translational Brain Medicine, 52074 Aachen, Germany.

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