Accelerated Failure Time Survival Model to Analyze Morris Water Maze Latency Data.
Morris water maze
latency
learning and memory
survival analysis
traumatic brain injury
Journal
Journal of neurotrauma
ISSN: 1557-9042
Titre abrégé: J Neurotrauma
Pays: United States
ID NLM: 8811626
Informations de publication
Date de publication:
15 02 2021
15 02 2021
Historique:
pubmed:
25
8
2020
medline:
25
11
2021
entrez:
25
8
2020
Statut:
ppublish
Résumé
Traumatic brain injury (TBI) induces cognitive deficits clinically and in animal models. Learning and memory testing is critical when evaluating potential therapeutic strategies and treatments to manage the effects of TBI. We evaluated three data analysis methods for the Morris water maze (MWM), a learning and memory assessment widely used in the neurotrauma field, to determine which statistical tool is optimal for MWM data. Hidden platform spatial MWM data aggregated from three separate experiments from the same laboratory were analyzed using 1) a logistic regression model, 2) an analysis of variance (ANOVA) model, and 3) an accelerated failure time (AFT) time-to-event model. The logistic regression model showed no significant evidence of differences between treatments among any swims over all days of the study,
Identifiants
pubmed: 32829672
doi: 10.1089/neu.2020.7089
pmc: PMC7875609
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
435-445Références
Sci Rep. 2017 Jul 27;7(1):6645
pubmed: 28751711
Exp Neurol. 2006 Oct;201(2):301-7
pubmed: 16764859
Stem Cell Res Ther. 2013 Jan 06;4(1):3
pubmed: 23290300
J Neurotrauma. 2020 Nov 15;37(22):2414-2423
pubmed: 30794049
J Neurosci Methods. 1984 May;11(1):47-60
pubmed: 6471907
J Neurotrauma. 2018 Dec 1;35(23):2737-2754
pubmed: 29756522
J Neurotrauma. 1992 Spring;9(1):11-20
pubmed: 1619672
Brain Res. 2004 Feb 13;998(1):113-21
pubmed: 14725974
J Vis Exp. 2018 Jan 30;(131):
pubmed: 29443022
Biometrics. 1994 Mar;50(1):61-76
pubmed: 8086616
Psychol Sci. 2014 Jan;25(1):7-29
pubmed: 24220629
Behav Brain Res. 2011 Aug 1;221(1):271-5
pubmed: 21397635
J Neurotrauma. 2013 May 1;30(9):688-701
pubmed: 23286417
Neurosci Biobehav Rev. 2018 May;88:187-200
pubmed: 29545166
PLoS One. 2013 Dec 17;8(12):e84492
pubmed: 24358362
Crit Care Med. 2019 Mar;47(3):480-483
pubmed: 30768509
J Neurotrauma. 2017 Mar 1;34(5):1086-1096
pubmed: 27650266