Utility of HAS-BLED and CHA
Aged
Aged, 80 and over
Anticoagulants
/ adverse effects
Atrial Fibrillation
/ complications
Cerebral Amyloid Angiopathy
/ complications
Female
Humans
Intracranial Hemorrhages
/ chemically induced
Magnetic Resonance Imaging
Male
Retrospective Studies
Risk Assessment
Risk Factors
Stroke
/ etiology
Tomography, X-Ray Computed
Journal
Mayo Clinic proceedings
ISSN: 1942-5546
Titre abrégé: Mayo Clin Proc
Pays: England
ID NLM: 0405543
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
13
11
2019
revised:
18
02
2020
accepted:
20
03
2020
pubmed:
25
8
2020
medline:
17
12
2020
entrez:
25
8
2020
Statut:
ppublish
Résumé
To determine the utility of the HAS-BLED (Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile international normalized ratio, Elderly, Drugs/alcohol concomitantly) and CHA Patients older than 55 years with a diagnosis of AF who had a nontraumatic intracerebral hemorrhage (ICH) while on AC therapy between 1995 and 2016 were identified using the Rochester Epidemiology Project Database. Medical records were reviewed, including imaging of the brain, to identify baseline characteristics, AC use, and outcomes. A total of 65 patients were identified (mean age, 81.3 years); 35 (53.8%) had evidence of possible/probable CAA. Mean HAS-BLED score in the CAA group was significantly lower (2.1) than that of the non-CAA group (2.9; P<.001). Mortality after ICH, adjusted for HAS-BLED scores, was not significantly different among patients with and without CAA. Sixteen patients restarted on AC therapy after ICH; CHA HAS-BLED scores were lower in patients who had evidence of CAA compared with those without, suggesting underestimation of ICH risk in patients with CAA. CHA
Identifiants
pubmed: 32829908
pii: S0025-6196(20)30401-8
doi: 10.1016/j.mayocp.2020.03.034
pmc: PMC8635034
mid: NIHMS1756718
pii:
doi:
Substances chimiques
Anticoagulants
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2090-2098Subventions
Organisme : NIA NIH HHS
ID : R01 AG034676
Pays : United States
Informations de copyright
Copyright © 2020 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.
Références
Eur Heart J. 2012 Jun;33(12):1500-10
pubmed: 22246443
Brain. 2017 Jul 1;140(7):1829-1850
pubmed: 28334869
Neurology. 2010 Aug 24;75(8):693-8
pubmed: 20733144
Neurology. 2010 Apr 27;74(17):1346-50
pubmed: 20421578
Neurology. 2017 Aug 22;89(8):820-829
pubmed: 28747441
Mayo Clin Proc. 2012 Feb;87(2):151-60
pubmed: 22305027
J Neurol Neurosurg Psychiatry. 2012 Mar;83(3):275-81
pubmed: 22056966
Mayo Clin Proc. 2016 Dec;91(12):1778-1810
pubmed: 27825618
J Stroke Cerebrovasc Dis. 2014 Nov-Dec;23(10):2479-2488
pubmed: 25440361
BMC Fam Pract. 2017 Jan 13;18(1):3
pubmed: 28086887
J Neurol. 2012 Feb;259(2):212-24
pubmed: 21748282
Stroke. 2003 Jul;34(7):1710-6
pubmed: 12805495
Clin Cardiol. 2014 Oct;37(10):634-44
pubmed: 25168181
PLoS One. 2018 Jan 25;13(1):e0191137
pubmed: 29370183
Neurology. 2000 Oct 10;55(7):947-51
pubmed: 11061249
J Neurol. 2018 Mar;265(3):567-577
pubmed: 29356971
J Am Coll Cardiol. 2011 Jan 11;57(2):173-80
pubmed: 21111555
Circ J. 2014;78(7):1593-9
pubmed: 24759791
Am J Epidemiol. 2011 May 1;173(9):1059-68
pubmed: 21430193
Neurol Clin Pract. 2018 Feb;8(1):48-57
pubmed: 29517050
Ann Intern Med. 2007 Jun 19;146(12):857-67
pubmed: 17577005
Arch Gerontol Geriatr. 2001 Nov-Dec;33(3):219-26
pubmed: 15374018
Chest. 2010 Nov;138(5):1093-100
pubmed: 20299623
Mayo Clin Proc. 2012 Dec;87(12):1202-13
pubmed: 23199802
Neurology. 2001 Feb 27;56(4):537-9
pubmed: 11222803
Stroke. 2017 Jun;48(6):1594-1600
pubmed: 28416626
Int J Epidemiol. 2012 Dec;41(6):1614-24
pubmed: 23159830
Circulation. 2014 Feb 25;129(8):837-47
pubmed: 24345399
Stroke. 1991 Aug;22(8):983-8
pubmed: 1866765
Chest. 2010 Feb;137(2):263-72
pubmed: 19762550
Cerebrovasc Dis. 2018;45(3-4):124-131
pubmed: 29558742
Blood. 2017 Jun 1;129(22):2980-2987
pubmed: 28356246
Lancet Neurol. 2018 Jun;17(6):539-547
pubmed: 29778365