Endocrine and Metabolic Insights from Pancreatic Surgery.
pancreatic disease
pancreatic surgery
personalized medicine
type 2 diabetes mellitus
Journal
Trends in endocrinology and metabolism: TEM
ISSN: 1879-3061
Titre abrégé: Trends Endocrinol Metab
Pays: United States
ID NLM: 9001516
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
07
04
2020
revised:
25
06
2020
accepted:
21
07
2020
pubmed:
25
8
2020
medline:
4
8
2021
entrez:
25
8
2020
Statut:
ppublish
Résumé
Although it is well established that diabetes can also develop as a result of diseases or maneuvers on the exocrine pancreas, the complex relationship between glucose disorders and underlying pancreatic disease is still debated. There is evidence that several features linked to pancreatic diseases can modify endocrine and metabolic conditions before and after surgery. However, pancreatic surgery provides a rare opportunity to correlate in vivo endocrine and metabolic pathways with ex vivo pancreatic samples, to examine the endocrine and metabolic effects of acute islet removal, and finally to clarify the pathogenesis of diabetes. This approach could therefore represent a unique method to shed light on the molecular mechanisms, predicting factors, and metabolic consequences of insulin resistance, islet plasticity, β cell failure, and type 2 diabetes.
Identifiants
pubmed: 32830029
pii: S1043-2760(20)30141-7
doi: 10.1016/j.tem.2020.07.003
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
760-772Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.