The relationship between famine exposure in early life and left atrial enlargement in adulthood.
adulthood
early life
famine exposure
left atrial enlargement
left atrium diameter
Journal
Journal of human nutrition and dietetics : the official journal of the British Dietetic Association
ISSN: 1365-277X
Titre abrégé: J Hum Nutr Diet
Pays: England
ID NLM: 8904840
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
14
05
2020
accepted:
09
07
2020
pubmed:
25
8
2020
medline:
15
12
2021
entrez:
25
8
2020
Statut:
ppublish
Résumé
Increased left atrium diameter (LAD) is associated with an elevated risk of cardiovascular diseases. The relationship between nutrition status and left atrial enlargement (LAE) is still unclear. The present study aimed to investigate the association of famine exposure in early life with LAE in adulthood. Participants were divided into non-exposed, fetal, early, middle and late childhood exposed groups according to birth data. LAE was defined when LAD was ≥3.9 cm in women and ≥4.1 cm in men, or ≥2.3 cm m In total, 2522 [905 male, mean (SD) age 59.1 (3.65) years] subjects were enrolled, including 392 (15.5%) LAE subjects. The prevalence of LAE in non-exposed, fetal, early, middle and late childhood exposed groups was 55 (10.8%), 38 (11.2%), 88 (18.1%), 102 (16.7%) and 109 (19.0%), respectively. Compared to the non-exposed group, the ORs for LAE were in fetal (OR = 0.956, 95% CI = 0.605-1.500, P = 0.847), late (OR = 1.748, 95% CI = 1.208-2.555, P = 0.003), middle (OR = 1.647, 95% CI = 1.140-2.403, P = 0.008) and early (OR = 1.630, 95% CI = 1.116-2.399, P = 0.012) childhood exposed groups after adjusting potential cofounders. When stratified by gender, smoking, body mass index, hypertension and diabetes, we found that the effect of famine exposure on LAE was only modified by diabetes (P Famine exposure during childhood stage might increase the risk of LAE in adults, and this effect interacts with diabetes.
Sections du résumé
BACKGROUND
Increased left atrium diameter (LAD) is associated with an elevated risk of cardiovascular diseases. The relationship between nutrition status and left atrial enlargement (LAE) is still unclear. The present study aimed to investigate the association of famine exposure in early life with LAE in adulthood.
METHODS
Participants were divided into non-exposed, fetal, early, middle and late childhood exposed groups according to birth data. LAE was defined when LAD was ≥3.9 cm in women and ≥4.1 cm in men, or ≥2.3 cm m
RESULTS
In total, 2522 [905 male, mean (SD) age 59.1 (3.65) years] subjects were enrolled, including 392 (15.5%) LAE subjects. The prevalence of LAE in non-exposed, fetal, early, middle and late childhood exposed groups was 55 (10.8%), 38 (11.2%), 88 (18.1%), 102 (16.7%) and 109 (19.0%), respectively. Compared to the non-exposed group, the ORs for LAE were in fetal (OR = 0.956, 95% CI = 0.605-1.500, P = 0.847), late (OR = 1.748, 95% CI = 1.208-2.555, P = 0.003), middle (OR = 1.647, 95% CI = 1.140-2.403, P = 0.008) and early (OR = 1.630, 95% CI = 1.116-2.399, P = 0.012) childhood exposed groups after adjusting potential cofounders. When stratified by gender, smoking, body mass index, hypertension and diabetes, we found that the effect of famine exposure on LAE was only modified by diabetes (P
CONCLUSIONS
Famine exposure during childhood stage might increase the risk of LAE in adults, and this effect interacts with diabetes.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
356-364Informations de copyright
© 2020 The British Dietetic Association Ltd.
Références
Douglas PS (2003) The left atrium: a biomarker of chronic diastolic dysfunction and cardiovascular disease risk. J Am Coll Cardiol 42, 1206-1207.
Pierdomenico SD, Pierdomenico AM, Di Carlo S et al. (2014) Left atrial enlargement and risk of ischemic stroke in elderly treated hypertensive patients. Am J Hypertens 27, 1179-1184.
Perlepe K, Sirimarco G, Strambo D et al. (2020) Left atrial diameter thresholds and new incident atrial fibrillation in embolic stroke of undetermined source. Eur J Intern Med 75, 30-34.
Parajuli P & Ahmed AA (2020) Left Atrial Enlargement. Treasure Island (FL): StatPearls.
Ou Q, Chen Y, Yu S et al. (2016) Prevalence of left atrial enlargement and its risk factors in general Chinese population. BMC Cardiovasc Disord 16, 53.
Al-Khadra Y, Darmoch F, Alkhatib M et al. (2018) Risk of left atrial enlargement in obese patients with obesity-induced hypoventilation syndrome vs obstructive sleep apnea. Ochsner J 18, 136-140.
Shigematsu Y, Norimatsu S, Ogimoto A et al. (2009) The influence of insulin resistance and obesity on left atrial size in Japanese hypertensive patients. Hypertens Res 32, 500-504.
Armstrong AC, Gidding SS, Colangelo LA et al. (2014) Association of early adult modifiable cardiovascular risk factors with left atrial size over a 20-year follow-up period: the CARDIA study. BMJ Open 4, e4001.
McManus DD, Yin X, Gladstone R et al. (2016) Alcohol consumption, left atrial diameter, and atrial fibrillation. J Am Heart Assoc 5, e004060.
Anees MA, Ahmad MI, Chevli PA et al. (2019) Association of vitamin D deficiency with electrocardiographic markers of left atrial abnormalities. Ann Noninvasive Electrocardiol 24, e12626.
Li Q, Heaney A, Langenfeld-McCoy N et al. (2019) Dietary intervention reduces left atrial enlargement in dogs with early preclinical myxomatous mitral valve disease: a blinded randomized controlled study in 36 dogs. BMC Vet Res 15, 425.
Speakman JR & Mitchell SE (2011) Caloric restriction. Mol Aspects Med 32, 159-221.
Scrimshaw NS (1987) The phenomenon of famine. Annu Rev Nutr 7, 1-21.
Painter RC, Roseboom TJ & Bleker OP (2005) Prenatal exposure to the Dutch famine and disease in later life: an overview. Reprod Toxicol 20, 345-352.
Roseboom TJ, Painter RC, van Abeelen AF et al. (2011) Hungry in the womb: what are the consequences? Lessons from the Dutch famine. Maturitas 70, 141-145.
Kyle UG & Pichard C (2006) The Dutch Famine of 1944-1945: a pathophysiological model of long-term consequences of wasting disease. Curr Opin Clin Nutr Metab Care 9, 388-394.
Roseboom T, de Rooij S & Painter R (2006) The Dutch famine and its long-term consequences for adult health. Early Hum Dev 82, 485-491.
Rong H, Lai X, Mahmoudi E et al. (2019) Early-life exposure to the Chinese Famine and risk of cognitive decline. J Clin Med 8, 484.
Nussbaumer J (1999) The great Chinese famine, 1958-61: introduction to the "descent" into the inferno. Zeitgesch 26, 127-153.
Lu J, Xuan S, Downing NS et al. (2016) Protocol for the China PEACE (Patient-centered Evaluative Assessment of Cardiac Events) Million Persons Project pilot. BMJ Open 6, e10200.
Misra A & Dhurandhar NV (2019) Current formula for calculating body mass index is applicable to Asian populations. Nutr Diabetes 9, 3.
Yang W, Lu J, Weng J et al. (2010) Prevalence of diabetes among men and women in China. N Engl J Med 362, 1090-1101.
Liu LS (2011) 2010 Chinese guidelines for the management of hypertension. Zhonghua Xin Xue Guan Bing Za Zhi 39, 579-615.
Lang RM, Bierig M, Devereux RB et al. (2005) Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 18, 1440-1463.
Bombelli M, Cuspidi C, Facchetti R et al. (2016) New-onset left atrial enlargement in a general population. J Hypertens 34, 1838-1845.
Hu YM, Wu XL, Hu ZH et al. (1999) Study of formula for calculating body surface areas of the Chinese adults. Sheng Li Xue Bao 51, 45-48.
Wang J, Li Y, Han X et al. (2016) Exposure to the Chinese famine in childhood increases type 2 diabetes risk in adults. J Nutr 146, 2289-2295.
Li Y, He Y, Qi L et al. (2010) Exposure to the Chinese famine in early life and the risk of hyperglycemia and type 2 diabetes in adulthood. Diabetes 59, 2400-2406.
Lindblom R, Ververis K, Tortorella SM et al. (2015) The early life origin theory in the development of cardiovascular disease and type 2 diabetes. Mol Biol Rep 42, 791-797.
de Rooij SR, Painter RC, Phillips DI et al. (2006) Hypothalamic-pituitary-adrenal axis activity in adults who were prenatally exposed to the Dutch famine. Eur J Endocrinol 155, 153-160.
Geraiely B, Tavoosi A, Sattarzadeh R et al. (2019) Board examination stress effect on diastolic function. J Clin Ultrasound 47, 139-143.
Margules DL (1980) Obesity and the development of the diffuse neuroendocrine system. Int J Obes 4, 296-303.