Hematoidin crystals in sputum smears: Cytopathology and clinical associations.
Carcinoma
Papanicolaou method
clinical associations
cytology
hematoidin crystals
lung
sputum smears
Journal
Annals of thoracic medicine
ISSN: 1817-1737
Titre abrégé: Ann Thorac Med
Pays: India
ID NLM: 101280721
Informations de publication
Date de publication:
Historique:
received:
22
02
2020
accepted:
04
04
2020
entrez:
25
8
2020
pubmed:
25
8
2020
medline:
25
8
2020
Statut:
ppublish
Résumé
There has been limited correlation of hematoidin crystals (HC) in sputum with clinical and diagnostic characteristics, partly because they are difficult to recognize. The aim of this study was, therefore, to assess these relationships in a consecutive cohort of sputum samples from patients submitted to a cytology laboratory. Adequate sputum samples from 489 individuals were enrolled in this study. These were fixed in ethanol, stained by the Papanicolaou method and examined microscopically. The normality of the distribution of the continuous variable (age in years) was examined using the Shapiro-Wilk normality test. As the data were not normally distributed, Kendall rank correlation was used to correlate age with the presence of HC. The Pearson's Chi-square test was used to determine if the proportion of cases with the presence of HC was different among the categorical data variables. A univariate binary logistic regression was used to determine the variables most strongly associated with HC presence. The results include odds ratios, 95% confidence intervals, Wald χ The presence of HC in sputum was associated with increasing age ( There are clear associations linked to the finding of HC in sputum that may be helpful in pointing to a specific diagnosis, such as the possibility of underlying carcinoma.
Sections du résumé
BACKGROUND
BACKGROUND
There has been limited correlation of hematoidin crystals (HC) in sputum with clinical and diagnostic characteristics, partly because they are difficult to recognize. The aim of this study was, therefore, to assess these relationships in a consecutive cohort of sputum samples from patients submitted to a cytology laboratory.
METHODS
METHODS
Adequate sputum samples from 489 individuals were enrolled in this study. These were fixed in ethanol, stained by the Papanicolaou method and examined microscopically. The normality of the distribution of the continuous variable (age in years) was examined using the Shapiro-Wilk normality test. As the data were not normally distributed, Kendall rank correlation was used to correlate age with the presence of HC. The Pearson's Chi-square test was used to determine if the proportion of cases with the presence of HC was different among the categorical data variables. A univariate binary logistic regression was used to determine the variables most strongly associated with HC presence. The results include odds ratios, 95% confidence intervals, Wald χ
RESULTS
RESULTS
The presence of HC in sputum was associated with increasing age (
CONCLUSIONS
CONCLUSIONS
There are clear associations linked to the finding of HC in sputum that may be helpful in pointing to a specific diagnosis, such as the possibility of underlying carcinoma.
Identifiants
pubmed: 32831938
doi: 10.4103/atm.ATM_69_20
pii: ATM-15-155
pmc: PMC7423204
doi:
Types de publication
Journal Article
Langues
eng
Pagination
155-162Informations de copyright
Copyright: © 2020 Annals of Thoracic Medicine.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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