Association of Serum FAM19A5 with Cognitive Impairment in Vascular Dementia.


Journal

Disease markers
ISSN: 1875-8630
Titre abrégé: Dis Markers
Pays: United States
ID NLM: 8604127

Informations de publication

Date de publication:
2020
Historique:
received: 10 06 2020
revised: 15 07 2020
accepted: 20 07 2020
entrez: 25 8 2020
pubmed: 25 8 2020
medline: 8 6 2021
Statut: epublish

Résumé

Family with sequence similarity 19 member A5 (FAM19A5), a novel chemokine-like peptide, is a secreted protein mainly expressed in the brain. FAM19A5 was recently found to be involved in a variety of neurological diseases; however, its correlation with vascular dementia (VaD) remains unclear. The aim of the study is to explore the association between serum FAM19A5 and cognitive impairment in subjects with VaD. 136 VaD subjects and 81 normal controls were recruited in the study. Their demographic and clinical baseline data were collected on admission. All subjects received Mini-Mental State Examination (MMSE) evaluation, which was used to test their cognitive functions. A sandwich enzyme-linked immunosorbent assay (ELISA) was applied to detect the serum levels of FAM19A5. No significant differences were found between the two groups regarding the demographic and clinical baseline data ( The serum FAM19A5 level of VaD patients is significantly increased, which may serve as a biomarker to predict cognitive function of VaD.

Identifiants

pubmed: 32831973
doi: 10.1155/2020/8895900
pmc: PMC7422492
doi:

Substances chimiques

Biomarkers 0
Cytokines 0
TAFA5 protein, human 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

8895900

Informations de copyright

Copyright © 2020 Juan Li et al.

Déclaration de conflit d'intérêts

The authors declare that they have no any conflict of interests.

Références

Biochem Biophys Res Commun. 2020 Mar 19;523(4):829-834
pubmed: 31954515
Neurology. 1993 Feb;43(2):250-60
pubmed: 8094895
Fetal Pediatr Pathol. 2019 Dec;38(6):496-502
pubmed: 31130048
Mol Med Rep. 2019 Nov;20(5):4477-4488
pubmed: 31702029
Brain Behav. 2016 Dec 05;7(2):e00617
pubmed: 28239527
Physiol Behav. 2019 Sep 1;208:112581
pubmed: 31220516
Neural Plast. 2020 Jun 12;2020:8834275
pubmed: 32617097
Circulation. 2018 Jul 3;138(1):48-63
pubmed: 29453251
Dis Markers. 2018 Sep 9;2018:2576026
pubmed: 30271507
FASEB J. 2019 Dec;33(12):14734-14747
pubmed: 31689372
Mol Psychiatry. 2020 Apr 21;:
pubmed: 32317715
Brain Res. 2008 Mar 14;1199:1-9
pubmed: 18275939
Dis Markers. 2015;2015:105358
pubmed: 26060332
Lancet. 2015 Oct 24;386(10004):1698-706
pubmed: 26595643
Brain Res Bull. 2019 Jul;149:168-174
pubmed: 31029599
Cell Transplant. 2019 Aug;28(8):1071-1075
pubmed: 31134827
Dis Markers. 2018 Oct 4;2018:5174815
pubmed: 30405860
Diab Vasc Dis Res. 2019 Nov;16(6):530-538
pubmed: 31280604
Nat Rev Neurol. 2014 Nov;10(11):634-42
pubmed: 25266297
J Neurol Sci. 2016 Mar 15;362:73-7
pubmed: 26944122
Brain Behav Immun. 2020 Jul;87:852-859
pubmed: 32217080
Int J Neurosci. 2016 Oct;126(10):899-903
pubmed: 26269142
Mol Cytogenet. 2018 Apr 27;11:26
pubmed: 29736186
Acta Biochim Biophys Sin (Shanghai). 2018 Oct 1;50(10):984-995
pubmed: 30137205
Dis Markers. 2020 Apr 21;2020:8641749
pubmed: 32377274
Front Neurosci. 2019 Aug 30;13:917
pubmed: 31543758
Brain Behav. 2020 Mar;10(3):e01542
pubmed: 31985179
Genomics. 2004 Apr;83(4):727-34
pubmed: 15028294
Lancet Neurol. 2020 Jan;19(1):81-92
pubmed: 31494009
Sci Rep. 2020 Mar 2;10(1):3969
pubmed: 32123192
Sci Rep. 2017 Nov 14;7(1):15575
pubmed: 29138422
Int J Neurosci. 2020 Jul;130(7):708-712
pubmed: 31847649

Auteurs

Juan Li (J)

Department of Neurology, The First People's Hospital of Lianyungang/ Department of Neurology, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu Province 222000, China.

Shoulin Li (S)

Department of Emergency Medicine, The First People's Hospital of Lianyungang/ Department of Neurology, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu Province 222000, China.

Yihong Song (Y)

Department of Neurology, The First People's Hospital of Lianyungang/ Department of Neurology, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu Province 222000, China.

Wei Zhou (W)

Department of Emergency Medicine, The First People's Hospital of Lianyungang/ Department of Neurology, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu Province 222000, China.

Xiaohao Zhu (X)

Department of Emergency Medicine, The First People's Hospital of Lianyungang/ Department of Neurology, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu Province 222000, China.

Suo Xu (S)

Department of Emergency Medicine, The First People's Hospital of Lianyungang/ Department of Neurology, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu Province 222000, China.

Yihong Ma (Y)

Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan.

Chunlin Zhu (C)

Department of Neurology, The First People's Hospital of Lianyungang/ Department of Neurology, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu Province 222000, China.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH