Depth-Dependent Corneal Biomechanical Properties in Normal and Keratoconic Subjects by Optical Coherence Elastography.
corneal biomechanics
elastography
keratoconus
optical coherence tomography
Journal
Translational vision science & technology
ISSN: 2164-2591
Titre abrégé: Transl Vis Sci Technol
Pays: United States
ID NLM: 101595919
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
02
01
2020
accepted:
07
04
2020
entrez:
25
8
2020
pubmed:
25
8
2020
medline:
25
8
2020
Statut:
epublish
Résumé
Compare depth-resolved biomechanical properties in normal and keratoconic corneas in live human subjects using optical coherence elastography (OCE). In a prospective series of normal and keratoconus (KC) eyes, a corneal perturbation was applied by a custom swept-source OCE system using a transparent flat lens coupled to force transducers. Cross-correlation was applied to track frame-by-frame OCT speckle displacement. Regional displacements for the anterior and posterior stroma were plotted in force versus displacement ( Thirty-six eyes were analyzed (21 eyes of 12 normal subjects and 15 KC eyes of 12 subjects). The Significant differences in depth-dependent corneal biomechanical properties were observed between normal and KC subjects. OCE was applied for the first time to human KC subjects and revealed alterations in the normal anterior-to-posterior stromal stiffness gradient, a novel and clinically accessible disease biomarker.
Identifiants
pubmed: 32832211
doi: 10.1167/tvst.9.7.4
pii: TVST-20-2227
pmc: PMC7414661
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
4Subventions
Organisme : NEI NIH HHS
ID : R01 EY023381
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY025585
Pays : United States
Informations de copyright
Copyright 2020 The Authors.
Déclaration de conflit d'intérêts
Disclosure: V.S. De Stefano, None; M.R. Ford, Cleveland Clinic (P); I. Seven, None; W.J. Dupps, Cleveland Clinic (P), Alcon (C), Zeiss (C), Glaukos (C)
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