A Mouse Model of Proliferative Vitreoretinopathy Induced by Intravitreal Injection of Gas and RPE Cells.

Animals Disease Models, Animal Intravitreal Injections Mice Rabbits Retina Tomography, Optical Coherence Vitreoretinopathy, Proliferative / chemically induced
contractile membranes mouse proliferative vitreoretinopathy retinal detachment

Journal

Translational vision science & technology
ISSN: 2164-2591
Titre abrégé: Transl Vis Sci Technol
Pays: United States
ID NLM: 101595919

Informations de publication

Date de publication:
06 2020
Historique:
received: 30 01 2020
accepted: 04 04 2020
entrez: 25 8 2020
pubmed: 25 8 2020
medline: 25 8 2020
Statut: epublish

Résumé

Develop a reproducible proliferative vitreoretinopathy (PVR) mouse model that mimics human PVR pathology. Mice received intravitreal injections of SF We report that mice that received gas before retinal pigment epithelial injection developed more severe PVR. In the 1 × 10 This mouse PVR model is reproducible and mimics aspects of PVR pathology reported in the rabbit PVR model and human PVR. The major advantage is the ability to study PVR development in different genetic backgrounds to further elucidate aspects of PVR pathogenesis. Additionally, large-scale experiments for testing pharmacologic agents to treat and prevent PVR progression is more feasible compared with other animal models. This model will provide a platform for screening potential drug therapies to treat and prevent PVR, as well as elucidate different molecular pathways involved in PVR pathogenesis.

Identifiants

DOI: 10.1167/tvst.9.7.9 PMID: 32832216 PMC: PMC7414640
pubmed: 32832216
doi: 10.1167/tvst.9.7.9
pii: TVST-20-2306
pmc: PMC7414640
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Pagination

9

Subventions

Organisme : NCATS NIH HHS
ID : TL1 TR002000
Pays : United States

Informations de copyright

Copyright 2020 The Authors.

Déclaration de conflit d'intérêts

Disclosure: A. Heffer, None; V. Wang, None; J. Sridhar, None; S.E. Feldon, None; R.T. Libby, None; C.F. Woeller, None; A.E. Kuriyan, None

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Auteurs

Alison Heffer (A)

Flaum Eye Institute, University of Rochester, Rochester, NY, USA.

Victor Wang (V)

Flaum Eye Institute, University of Rochester, Rochester, NY, USA.

Jayanth Sridhar (J)

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

Steven E Feldon (SE)

Flaum Eye Institute, University of Rochester, Rochester, NY, USA.
Center for Visual Sciences, University of Rochester, Rochester, NY, USA.

Richard T Libby (RT)

Flaum Eye Institute, University of Rochester, Rochester, NY, USA.
Center for Visual Sciences, University of Rochester, Rochester, NY, USA.

Collynn F Woeller (CF)

Flaum Eye Institute, University of Rochester, Rochester, NY, USA.

Ajay E Kuriyan (AE)

Retina Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.
Flaum Eye Institute, University of Rochester, Rochester, NY, USA.
Center for Visual Sciences, University of Rochester, Rochester, NY, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A Mouse Model of Proliferative...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › A Mouse Model of Proliferative...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Injections › Injections oculaires › Injections intravitréennes › A Mouse Model of Proliferative...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A Mouse Model of Proliferative...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Lagomorpha › Lapins › A Mouse Model of Proliferative...
questionsmedicales.fr › Organes des sens › Oeil › Rétine › A Mouse Model of Proliferative...
questionsmedicales.fr › Techniques d'investigation › Imagerie optique › Tomographie optique › Tomographie par cohérence optique › A Mouse Model of Proliferative...
questionsmedicales.fr › Maladies de l'oeil › Rétinopathies › Vitréorétinopathie proliférante › A Mouse Model of Proliferative...