A Custom-Made Semiautomatic Analysis of Retinal Nonperfusion Areas After Dexamethasone for Diabetic Macular Edema.
diabetic macular edema
intravitreal dexamethasone implant
retinal nonperfusion areas
widefield OCT angiography
Journal
Translational vision science & technology
ISSN: 2164-2591
Titre abrégé: Transl Vis Sci Technol
Pays: United States
ID NLM: 101595919
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
30
01
2020
accepted:
29
03
2020
entrez:
25
8
2020
pubmed:
25
8
2020
medline:
25
8
2020
Statut:
epublish
Résumé
To evaluate the changes of retinal capillary nonperfusion areas and retinal capillary vessel density of the superficial capillary plexus (SCP) and deep capillary plexus in patients with diabetes with diabetic macular edema treated with an intravitreal dexamethasone implant (IDI). We enrolled 28 patients with diabetic retinopathy and diabetic macular edema candidates to IDI. All patients underwent widefield optical coherence tomography angiography with PLEX Elite 9000 device with 15 × 9 mm scans centered on the foveal center at baseline, 1 month, 2 months, and 4 months after IDI. In all the patients, the variation of the retinal capillary nonperfusion areas and of the retinal vessel density of the SCP and deep capillary plexus were calculated using an automatic software written in Matlab (MathWorks, Natick, MA). During follow-up, SCP showed a statistically significant reduction of ischemic areas at 1 month after IDI ( Widefield optical coherence tomography angiography showed a decrease in retinal capillary nonperfusion areas after dexamethasone implant suggesting a possible drug-related reperfusion of retinal capillaries particularly evident in the early period. A custom-made automatic analysis of retinal nonperfusion areas may allow a better and precise evaluation of ischemic changes after intravitreal therapy.
Identifiants
pubmed: 32832220
doi: 10.1167/tvst.9.7.13
pii: TVST-20-2308
pmc: PMC7414703
doi:
Substances chimiques
Dexamethasone
7S5I7G3JQL
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
13Informations de copyright
Copyright 2020 The Authors.
Déclaration de conflit d'intérêts
Disclosure: L. Toto, None; R. D'Aloisio, None; A.M. Chiarelli, None; L. Di Antonio, None; F. Evangelista, None; G. D'Onofrio, None; A. Merla, None; M. Parravano, None; G. Di Marzio, None; R. Mastropasqua, None
Références
Invest Ophthalmol Vis Sci. 2011 Jun 28;52(7):4605-9
pubmed: 21421864
Am J Pathol. 2004 Jul;165(1):35-52
pubmed: 15215160
Acta Ophthalmol. 2018 Aug;96(5):e647-e648
pubmed: 27641955
Br J Ophthalmol. 2019 Feb;103(2):216-221
pubmed: 29706601
Int J Mol Sci. 2017 Jun 02;18(6):
pubmed: 28574436
Proc Natl Acad Sci U S A. 2015 May 5;112(18):E2395-402
pubmed: 25897021
Int J Ophthalmol. 2017 Oct 18;10(10):1545-1551
pubmed: 29062774
Retina. 2019 Mar;39(3):426-434
pubmed: 30664126
J Ocul Pharmacol Ther. 2014 Dec;30(10):854-8
pubmed: 25411827
Asia Pac J Ophthalmol (Phila). 2018 Jan-Feb;7(1):46-51
pubmed: 29436208
Ophthalmology. 2019 Aug;126(8):1171-1180
pubmed: 30946887
Retina. 2020 Mar;40(3):412-420
pubmed: 30576300
Ophthalmology. 2014 Sep;121(9):1783-9
pubmed: 24768239
Ophthalmology. 2015 Dec;122(12):2465-72
pubmed: 26350546
J Biophotonics. 2017 Nov;10(11):1464-1472
pubmed: 28493437
Korean J Ophthalmol. 2019 Aug;33(4):359-365
pubmed: 31389212
Acta Diabetol. 2017 Jul;54(7):695-702
pubmed: 28474119
Prog Retin Eye Res. 2017 Sep;60:66-100
pubmed: 28760677
Invest Ophthalmol Vis Sci. 2011 Jan 05;52(1):80-6
pubmed: 20702826
Ophthalmology. 2003 Sep;110(9):1677-82
pubmed: 13129861
Am J Ophthalmol. 2014 Jul;158(1):144-153.e1
pubmed: 24709807
Ophthalmology. 2019 Dec;126(12):1685-1694
pubmed: 31383483
Ophthalmology. 1991 May;98(5 Suppl):834-40
pubmed: 2062516
Acta Diabetol. 2019 Dec;56(12):1293-1303
pubmed: 31468199
Diabetes Care. 2012 Mar;35(3):556-64
pubmed: 22301125
Retina. 2010 May;30(5):781-6
pubmed: 20464787
Br J Ophthalmol. 2012 May;96(5):694-8
pubmed: 22423055
JCI Insight. 2017 Sep 21;2(18):
pubmed: 28931763
Acta Diabetol. 2017 Aug;54(8):769-773
pubmed: 28577137
Retina. 2015 Nov;35(11):2196-203
pubmed: 25932558