Shattering barriers toward clinically meaningful MSC therapies.
Batch Cell Culture Techniques
/ methods
Betacoronavirus
Bioreactors
COVID-19
Coronavirus Infections
/ therapy
Graft vs Host Disease
/ therapy
Humans
Mesenchymal Stem Cell Transplantation
/ methods
Mesenchymal Stem Cells
/ metabolism
Metabolic Engineering
/ methods
Pandemics
Pneumonia, Viral
/ therapy
SARS-CoV-2
Transplant Recipients
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
23
12
2019
accepted:
05
06
2020
entrez:
25
8
2020
pubmed:
25
8
2020
medline:
22
9
2020
Statut:
epublish
Résumé
More than 1050 clinical trials are registered at FDA.gov that explore multipotent mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable, including neurodegenerative and cardiac disorders, perianal fistulas, graft-versus-host disease, COVID-19, and cancer. Several companies have or are in the process of commercializing MSC-based therapies. However, most of the clinical-stage MSC therapies have been unable to meet primary efficacy end points. The innate therapeutic functions of MSCs administered to humans are not as robust as demonstrated in preclinical studies, and in general, the translation of cell-based therapy is impaired by a myriad of steps that introduce heterogeneity. In this review, we discuss the major clinical challenges with MSC therapies, the details of these challenges, and the potential bioengineering approaches that leverage the unique biology of MSCs to overcome the challenges and achieve more potent and versatile therapies.
Identifiants
pubmed: 32832666
doi: 10.1126/sciadv.aba6884
pii: aba6884
pmc: PMC7439491
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
eaba6884Subventions
Organisme : NIH HHS
ID : HL095722
Pays : United States
Organisme : NIH HHS
ID : NS107857
Pays : United States
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
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