Age and mitochondrial DNA copy number influence the association between outdoor temperature and cognitive function: Insights from the VA Normative Aging Study.
Journal
Environmental epidemiology (Philadelphia, Pa.)
ISSN: 2474-7882
Titre abrégé: Environ Epidemiol
Pays: United States
ID NLM: 101719527
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
26
09
2019
accepted:
29
06
2020
entrez:
25
8
2020
pubmed:
25
8
2020
medline:
25
8
2020
Statut:
epublish
Résumé
General cognitive function deteriorates with aging, a change that has been linked to outdoor temperature. Older individuals have reduced ability to adapt to changes in outdoor temperature than younger people. However, to what extent short-term changes in outdoor temperature interact with mitochondria to affect cognition in older people has not yet been determined. Our study included 591 participants of the Normative Aging Study who underwent multiple examinations between 2000 and 2013. Cognitive function was evaluated via the Mini-Mental State Examination. Outdoor temperature was estimated at residential addresses 1 day before the examination using on a validated spatiotemporal temperature model. Mitochondrial DNA copy number (mtDNAcn) was determined using buffy coat samples. We found an interaction between temperature, age, mtDNAcn, and cognition. In individuals 84 years of age or older, cooler temperature was associated with low cognition (odds ratio = 1.2; 95% confidence interval = 1.05, 1.35 for a 1°C decrease in temperature; Our findings, albeit potentially underpowered, suggest that older individuals may be more susceptible to the influence of short-term temperature exposure on cognition. Moreover, the level of mtDNAcn may also modify the association between temperature and cognitive function, indicating a possible role of these cellular elements in this relationship.
Sections du résumé
BACKGROUND
BACKGROUND
General cognitive function deteriorates with aging, a change that has been linked to outdoor temperature. Older individuals have reduced ability to adapt to changes in outdoor temperature than younger people. However, to what extent short-term changes in outdoor temperature interact with mitochondria to affect cognition in older people has not yet been determined.
METHODS
METHODS
Our study included 591 participants of the Normative Aging Study who underwent multiple examinations between 2000 and 2013. Cognitive function was evaluated via the Mini-Mental State Examination. Outdoor temperature was estimated at residential addresses 1 day before the examination using on a validated spatiotemporal temperature model. Mitochondrial DNA copy number (mtDNAcn) was determined using buffy coat samples.
RESULTS
RESULTS
We found an interaction between temperature, age, mtDNAcn, and cognition. In individuals 84 years of age or older, cooler temperature was associated with low cognition (odds ratio = 1.2; 95% confidence interval = 1.05, 1.35 for a 1°C decrease in temperature;
CONCLUSIONS
CONCLUSIONS
Our findings, albeit potentially underpowered, suggest that older individuals may be more susceptible to the influence of short-term temperature exposure on cognition. Moreover, the level of mtDNAcn may also modify the association between temperature and cognitive function, indicating a possible role of these cellular elements in this relationship.
Identifiants
pubmed: 32832843
doi: 10.1097/EE9.0000000000000108
pmc: PMC7423527
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e0108Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES009089
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES021357
Pays : United States
Informations de copyright
Copyright © 2020 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The Environmental Epidemiology. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest with regard to the content of this report.
Références
Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):504-11
pubmed: 11138842
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
Sci Total Environ. 2012 Aug 15;432:85-92
pubmed: 22721687
Exp Biol Med (Maywood). 2002 Oct;227(9):671-82
pubmed: 12324649
Occup Environ Med. 2007 Feb;64(2):93-100
pubmed: 16990293
Eur J Epidemiol. 2014 Feb;29(2):133-40
pubmed: 24553905
Age Ageing. 2012 May;41(3):299-308
pubmed: 22374645
Am J Epidemiol. 2000 Apr 1;151(7):676-88
pubmed: 10752795
Nature. 2016 Nov 24;539(7630):555-559
pubmed: 27828947
Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):486-91
pubmed: 24297907
Epidemiology. 2007 Jan;18(1):59-66
pubmed: 17130688
Intern Med J. 2001 Jul;31(5):290-5
pubmed: 11512600
Mitochondrion. 2013 Sep;13(5):481-92
pubmed: 23085537
Environ Health. 2013 Feb 15;12:16
pubmed: 23413885
Environ Health Perspect. 2011 May;119(5):682-7
pubmed: 21172758
Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):514-9
pubmed: 9012815
Epigenetics. 2010 Apr;5(3):222-8
pubmed: 20305373
Environ Health Perspect. 2010 Jul;118(7):943-8
pubmed: 20211803
Int J Obes (Lond). 2010 Oct;34 Suppl 1:S47-55
pubmed: 20935667
Ergonomics. 2012;55(7):792-8
pubmed: 22506538
Neurology. 2012 Mar 27;78(13):964-8
pubmed: 22402861
Diabetes Res Clin Pract. 2009 Nov;86(2):e22-4
pubmed: 19660820
J Cardiovasc Transl Res. 2019 Dec 11;:
pubmed: 31828536
J Am Geriatr Soc. 1992 Sep;40(9):922-35
pubmed: 1512391
Environ Res. 2016 Oct;150:446-451
pubmed: 27391696
Epidemiology. 2000 Sep;11(5):550-60
pubmed: 10955408
Mitochondrion. 2009 Jul;9(4):242-6
pubmed: 19272467
Circulation. 2016 Jan 26;133(4):378-87
pubmed: 26660284
Aviat Space Environ Med. 2007 Jun;78(6):568-73
pubmed: 17571656
J Gerontol. 1972 Apr;27(2):202-8
pubmed: 5060722
Environ Health Perspect. 2014 Dec;122(12):1271-8
pubmed: 25127496