The Orphan G-Protein Coupled Receptor 182 Is a Negative Regulator of Definitive Hematopoiesis through Leukotriene B4 Signaling.
Journal
ACS pharmacology & translational science
ISSN: 2575-9108
Titre abrégé: ACS Pharmacol Transl Sci
Pays: United States
ID NLM: 101721411
Informations de publication
Date de publication:
14 Aug 2020
14 Aug 2020
Historique:
received:
19
02
2020
entrez:
25
8
2020
pubmed:
25
8
2020
medline:
25
8
2020
Statut:
epublish
Résumé
The G protein-coupled receptor 182 (GPR182) is an orphan GPCR, the expression of which is enriched in embryonic endothelial cells (ECs). However, the physiological role and molecular mechanism of action of GPR182 are unknown. Here, we show that GPR182 negatively regulates definitive hematopoiesis in zebrafish and mice. In zebrafish,
Identifiants
pubmed: 32832870
doi: 10.1021/acsptsci.0c00020
pmc: PMC7432686
doi:
Types de publication
Journal Article
Langues
eng
Pagination
676-689Subventions
Organisme : NICHD NIH HHS
ID : R01 HD060860
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA071341
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK099156
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL129086
Pays : United States
Organisme : NHLBI NIH HHS
ID : F32 HL134279
Pays : United States
Informations de copyright
Copyright © 2020 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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