Conformational Changes in Tyrosine 11 of Neurotensin Are Required to Activate the Neurotensin Receptor 1.


Journal

ACS pharmacology & translational science
ISSN: 2575-9108
Titre abrégé: ACS Pharmacol Transl Sci
Pays: United States
ID NLM: 101721411

Informations de publication

Date de publication:
14 Aug 2020
Historique:
received: 03 03 2020
entrez: 25 8 2020
pubmed: 25 8 2020
medline: 25 8 2020
Statut: epublish

Résumé

Cell-cell communication via endogenous peptides and their receptors is vital for controlling all aspects of human physiology and most peptides signal through G protein-coupled receptors (GPCRs). Disordered peptides bind GPCRs through complex modes for which there are few representative crystal structures. The disordered peptide neurotensin (NT) is a neuromodulator of classical neurotransmitters such as dopamine and glutamate, through activation of neurotensin receptor 1 (NTS

Identifiants

pubmed: 32832871
doi: 10.1021/acsptsci.0c00026
pmc: PMC7432660
doi:

Types de publication

Journal Article

Langues

eng

Pagination

690-705

Informations de copyright

Copyright © 2020 American Chemical Society.

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

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Auteurs

Fabian Bumbak (F)

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3010, Australia.
Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.
Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia.

Trayder Thomas (T)

Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

Billy J Noonan-Williams (BJ)

Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

Tasneem M Vaid (TM)

Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.
Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia.
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3010, Australia.

Fei Yan (F)

Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.
Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia.

Alice R Whitehead (AR)

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3010, Australia.

Shoni Bruell (S)

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3010, Australia.

Martina Kocan (M)

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3010, Australia.
The School of BioSciences, The University of Melbourne, Parkville, Victoria 3010, Australia.

Xuan Tan (X)

Department of Chemistry, The University of Alabama at Birmingham, Birmingham, Alabama 35294-1240, United States.

Margaret A Johnson (MA)

Department of Chemistry, The University of Alabama at Birmingham, Birmingham, Alabama 35294-1240, United States.

Ross A D Bathgate (RAD)

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3010, Australia.
Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.

David K Chalmers (DK)

Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

Paul R Gooley (PR)

Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.
Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia.

Daniel J Scott (DJ)

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3010, Australia.
Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.

Classifications MeSH