Mass Spectrometric Quantitation of Apurinic/Apyrimidinic Sites in Tissue DNA of Rats Exposed to Tobacco-Specific Nitrosamines and in Lung and Leukocyte DNA of Cigarette Smokers and Nonsmokers.

Animals DNA / drug effects DNA Damage Humans Leukocytes / drug effects Lung / drug effects Male Mass Spectrometry Nitrosamines / administration & dosage Non-Smokers Rats Rats, Inbred F344 Smokers Nicotiana / chemistry Tobacco Products / analysis

Journal

Chemical research in toxicology
ISSN: 1520-5010
Titre abrégé: Chem Res Toxicol
Pays: United States
ID NLM: 8807448

Informations de publication

Date de publication:
21 09 2020
Historique:
pubmed: 25 8 2020
medline: 24 8 2021
entrez: 25 8 2020
Statut: ppublish

Résumé

Metabolic activation of the carcinogenic tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and

Identifiants

DOI: 10.1021/acs.chemrestox.0c00265 PMID: 32833447 PMC: PMC7574376
pubmed: 32833447
doi: 10.1021/acs.chemrestox.0c00265
pmc: PMC7574376
mid: NIHMS1636281
doi:

Substances chimiques

Nitrosamines 0
DNA 9007-49-2

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

2475-2486

Subventions

Organisme : NCI NIH HHS
ID : P30 CA077598
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA160032
Pays : United States
Organisme : NCI NIH HHS
ID : N01 PC064402
Pays : United States
Organisme : NCI NIH HHS
ID : R37 CA081301
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA081301
Pays : United States

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Auteurs

Jiehong Guo (J)

Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States.
ORCID: 0000-0002-1680-5159

Haoqing Chen (H)

Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States.
ORCID: 0000-0002-4290-6092

Pramod Upadhyaya (P)

Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States.

Yingchun Zhao (Y)

Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States.

Robert J Turesky (RJ)

Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States.
ORCID: 0000-0001-7355-9903

Stephen S Hecht (SS)

Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States.
ORCID: 0000-0001-7228-1356

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mass Spectrometric Quantitation of...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Mass Spectrometric Quantitation of...
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › Mass Spectrometric Quantitation of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mass Spectrometric Quantitation of...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Mass Spectrometric Quantitation of...
questionsmedicales.fr › Appareil respiratoire › Poumon › Mass Spectrometric Quantitation of...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Mass Spectrometric Quantitation of...
questionsmedicales.fr › Composés chimiques organiques › Composés nitrosés › Nitrosamines › Mass Spectrometric Quantitation of...
questionsmedicales.fr › Personnes › Non-fumeurs › Mass Spectrometric Quantitation of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Mass Spectrometric Quantitation of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Lignées consanguines de rats › Rats de lignée F344 › Mass Spectrometric Quantitation of...
questionsmedicales.fr › Personnes › Fumeurs › Mass Spectrometric Quantitation of...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Dispositifs pour fumer › Produits du tabac › Mass Spectrometric Quantitation of...