Myo/Nog cells are nonprofessional phagocytes.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
04
11
2019
accepted:
24
06
2020
entrez:
25
8
2020
pubmed:
25
8
2020
medline:
2
10
2020
Statut:
epublish
Résumé
Myo/Nog cells were discovered in the chick embryo epiblast. Their expression of MyoD reflects a commitment to the skeletal muscle lineage and capacity to differentiate into myofibroblasts. Release of Noggin by Myo/Nog cells is essential for normal morphogenesis. Myo/Nog cells rapidly respond to wounding in the skin and eyes. In this report, we present evidence suggesting that Myo/Nog cells phagocytose tattoo ink in tissue sections of human skin and engulf cell corpses in cultures of anterior human lens tissue and magnetic beads injected into the anterior chamber of mice in vivo. Myo/Nog cells are distinct from macrophages in the skin and eyes indicated by the absence of labeling with an antibody to ionized calcium binding adaptor molecule 1. In addition to their primary roles as regulators of BMP signaling and progenitors of myofibroblasts, Myo/Nog cells behave as nonprofessional phagocytes defined as cells whose primary functions are unrelated to phagocytosis but are capable of engulfment.
Identifiants
pubmed: 32833999
doi: 10.1371/journal.pone.0235898
pii: PONE-D-19-30710
pmc: PMC7446839
doi:
Substances chimiques
Carrier Proteins
0
MyoD Protein
0
noggin protein
148294-77-3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0235898Déclaration de conflit d'intérêts
There are no competing interests related to this manuscript.
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