Encephalitis associated with the SARS-CoV-2 virus: A case report.

COVID-19 Encephalitis Hydroxychloroquine Neurological complications SARS-CoV-2

Journal

Interdisciplinary neurosurgery : Advanced techniques and case management
ISSN: 2214-7519
Titre abrégé: Interdiscip Neurosurg
Pays: Netherlands
ID NLM: 101648481

Informations de publication

Date de publication:
Dec 2020
Historique:
received: 29 06 2020
accepted: 04 07 2020
entrez: 25 8 2020
pubmed: 25 8 2020
medline: 25 8 2020
Statut: ppublish

Résumé

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) usually causes fever, respiratory symptoms, malaise and myalgia. Recent observations suggested possible neurological complications of COVID-19, including the first report of suspected viral encephalitis. We report a case of a 29-year-old male with -on nasopharyngeal testing- confirmed SARS-CoV-2 infection with severe respiratory symptoms, followed by clinical and radiological signs of encephalitis. Magnetic resonance imaging (MRI) of the brain showed an asymmetric FLAIR-hyperintensity of the left medial temporal cortex associated with mild gyral expansion. Lumbar puncture was normal and PCR's for SARS-CoV-2 virus on CSF were negative. Clinicians treating SARS-CoV-2 infected patients should be aware of possible neurological complications, like encephalitis. The diagnosis of SARS-CoV-2 encephalitis is difficult as CSF analysis may be normal.

Identifiants

pubmed: 32835017
doi: 10.1016/j.inat.2020.100821
pii: S2214-7519(20)30382-0
pii: 100821
pmc: PMC7347479
doi:

Types de publication

Journal Article

Langues

eng

Pagination

100821

Informations de copyright

© 2020 Published by Elsevier B.V.

Déclaration de conflit d'intérêts

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Références

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Auteurs

Fenne Vandervorst (F)

Department of Neurology, UZ Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel, Belgium.

Kaat Guldolf (K)

Department of Neurology, UZ Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel, Belgium.

Ilse Peeters (I)

Department of Neurology, UZ Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel, Belgium.

Tim Vanderhasselt (T)

Department of Radiology, UZ Brussel, Vrije Universiteit Brussel, Belgium.

Kathleen Michiels (K)

Department of Neurology, UZ Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel, Belgium.

Kinge Johanna Berends (KJ)

Department of Psychiatry, UZ Brussel, Vrije Universiteit Brussel, Belgium.

Johan Van Laethem (J)

Department of Internal Medicine and Endocrinology, UZ Brussel, Vrije Universiteit Brussel, Belgium.

Lissa Pipeleers (L)

Department of Nephrology, UZ Brussel, Vrije Universiteit Brussel, Belgium.

Stefanie Vincken (S)

Department of Pneumology, UZ Brussel, Vrije Universiteit Brussel, Belgium.

Laura Seynaeve (L)

Department of Neurology, UZ Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel, Belgium.

Sebastiaan Engelborghs (S)

Department of Neurology, UZ Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel, Belgium.

Classifications MeSH