A multicenter consensus: A role of furin in the endothelial tropism in obese patients with COVID-19 infection.
COVID-19
Chinese herbals
Endothelial pathogenicity
Furin
Ion channel inhibitors
Polybasic cleavage site
Journal
Obesity medicine
ISSN: 2451-8476
Titre abrégé: Obes Med
Pays: England
ID NLM: 101690300
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
30
06
2020
revised:
07
07
2020
accepted:
08
07
2020
entrez:
25
8
2020
pubmed:
25
8
2020
medline:
25
8
2020
Statut:
ppublish
Résumé
Furin, a cleavage enzyme, is increasingly recognized in the pathogenesis of metabolic syndrome. Its cleavage action is an essential activation step for the endothelial pathogenicity of several viruses including SARS-CoV-2. This Furin-mediated endothelial tropism seems to underlie the multi-organ system involvement of COVID-19; which is a feature that was not recognized in the older versions of coronaviridae. Obese and diabetic patients, males, and the elderly, have increased serum levels of Furin, with its increased cellular activity; this might explain why these subgroups are at an increased risk of COVID-19 related complications and deaths. In contrast, smoking decreases cellular levels of Furin, this finding may be at the origin of the decreased severity of COVID-19 in smokers. Chinese herbal derived luteolin is suggested to be putative Furin inhibitor, with previous success against Dengue Fever. Additionally, Furin intracellular levels are largely dependent on concentration of intracellular ions, notably sodium, potassium, and magnesium. Consequently, the use of ion channel inhibitors, such as Calcium Channel blockers or Potassium Channel blockers, can prevent cellular transfection early in the course of the illness. Nicotine patches and Colchicine have also been suggested as potential therapies due to Furin mediated inhibition of COVID-19.
Identifiants
pubmed: 32835124
doi: 10.1016/j.obmed.2020.100281
pii: S2451-8476(20)30101-9
pii: 100281
pmc: PMC7362855
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
100281Informations de copyright
© 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest.
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