Polymorphisms in the
Addison’s
CTLA-4
Canine
Hypoadrenocorticism
Promoter
Journal
Canine medicine and genetics
ISSN: 2662-9380
Titre abrégé: Canine Med Genet
Pays: England
ID NLM: 101763636
Informations de publication
Date de publication:
2020
2020
Historique:
received:
07
11
2019
accepted:
18
02
2020
entrez:
25
8
2020
pubmed:
25
8
2020
medline:
25
8
2020
Statut:
epublish
Résumé
Canine hypoadrenocorticism is an immune-mediated endocrinopathy that shares both clinical and pathophysiological similarities with Addison's disease in humans. Several dog breeds are overrepresented in the disease population, suggesting that a genetic component is involved, although this is likely to be polygenic. Previous research has implicated Polymorphisms in the CTLA4 promoter were determined by PCR and sequence-based typing. There were significant associations with three promoter haplotypes in cocker spaniels ( This study provides further evidence that
Sections du résumé
BACKGROUND
BACKGROUND
Canine hypoadrenocorticism is an immune-mediated endocrinopathy that shares both clinical and pathophysiological similarities with Addison's disease in humans. Several dog breeds are overrepresented in the disease population, suggesting that a genetic component is involved, although this is likely to be polygenic. Previous research has implicated
RESULTS
RESULTS
Polymorphisms in the CTLA4 promoter were determined by PCR and sequence-based typing. There were significant associations with three promoter haplotypes in cocker spaniels (
CONCLUSIONS
CONCLUSIONS
This study provides further evidence that
Identifiants
pubmed: 32835228
doi: 10.1186/s40575-020-0081-4
pii: 81
pmc: PMC7371821
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2Informations de copyright
© The Author(s). 2020.
Déclaration de conflit d'intérêts
Competing interestsLorna J Kennedy is Managing Editor on Canine Medicine and Genetics. However, she will not be involved in the decision-making of this paper. The other authors declare no competing interests.
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