SIX6 is a TAL1-regulated transcription factor in T-ALL and associated with inferior outcome.

Animals Basic Helix-Loop-Helix Transcription Factors / genetics Cell Line, Tumor Homeodomain Proteins Humans Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics Proto-Oncogene Proteins / genetics T-Cell Acute Lymphocytic Leukemia Protein 1 Trans-Activators Zebrafish / genetics
SIX6 T-cell acute lymphoblastic leukemia TAL1 aberrant gene expression event-free survival

Journal

Leukemia & lymphoma
ISSN: 1029-2403
Titre abrégé: Leuk Lymphoma
Pays: United States
ID NLM: 9007422

Informations de publication

Date de publication:
12 2020
Historique:
pubmed: 25 8 2020
medline: 28 4 2021
entrez: 25 8 2020
Statut: ppublish

Résumé

T-cell acute lymphoblastic leukemia (T-ALL) is a hematological malignancy driven by abnormal activity of transcription factors. Here we report an aberrant expression of the developmental transcription factor

Identifiants

DOI: 10.1080/10428194.2020.1804560 PMID: 32835548
pubmed: 32835548
doi: 10.1080/10428194.2020.1804560
doi:

Substances chimiques

Basic Helix-Loop-Helix Transcription Factors 0
Homeodomain Proteins 0
Proto-Oncogene Proteins 0
SIX6 protein, human 0
T-Cell Acute Lymphocytic Leukemia Protein 1 0
Trans-Activators 0
TAL1 protein, human 135471-20-4

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3089-3100

Auteurs

Saara Laukkanen (S)

Faculty of Medicine and Health Technology, Tampere Center for Child Health Research, Tampere University, Tampere, Finland.
ORCID: 0000-0001-6328-1741

Laura Oksa (L)

Faculty of Medicine and Health Technology, Tampere Center for Child Health Research, Tampere University, Tampere, Finland.

Atte Nikkilä (A)

Faculty of Medicine and Health Technology, Tampere Center for Child Health Research, Tampere University, Tampere, Finland.

Mari Lahnalampi (M)

The Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.

Mataleena Parikka (M)

Faculty of Medicine and Health Technology, BioMediTech, Tampere University, Tampere, Finland.
Oral and Maxillofacial Unit, Tampere University Hospital, Tampere, Finland.
ORCID: 0000-0001-5555-3815

Masafumi Seki (M)

Department of Cell and Molecular Biology, Karolinska Institutet, Solna, Sweden.

Junko Takita (J)

Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Sofie Degerman (S)

Department of Medical Biosciences and Department of Clinical Microbiology, Umeå University, Umeå, Sweden.
ORCID: 0000-0002-2783-0712

Charles E de Bock (CE)

Children's Cancer Institute, Lowy Cancer Research Centre, Sydney, Australia.
School of Women's and Children's Health, University of New South Wales Sydney, Sydney, Australia.

Merja Heinäniemi (M)

The Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
ORCID: 0000-0001-6190-3439

Olli Lohi (O)

Faculty of Medicine and Health Technology, Tampere Center for Child Health Research, Tampere University, Tampere, Finland.
Tays Cancer Centre, Tampere University Hospital, Tampere, Finland.
ORCID: 0000-0001-9195-0797

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › SIX6 is a TAL1-regulated transcription factor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique hélice-boucle-hélice › SIX6 is a TAL1-regulated transcription factor...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › SIX6 is a TAL1-regulated transcription factor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Protéines à homéodomaine › SIX6 is a TAL1-regulated transcription factor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › SIX6 is a TAL1-regulated transcription factor...
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Leucémie lymphoïde › Leucémie-lymphome lymphoblastique à précurseurs B et T › Leucémie-lymphome lymphoblastique à précurseurs T › SIX6 is a TAL1-regulated transcription factor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › SIX6 is a TAL1-regulated transcription factor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique hélice-boucle-hélice › Protéine-1 de la lleucémie lymphoïde aiguë à cellules T › SIX6 is a TAL1-regulated transcription factor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales régulatrices ou accessoires › Transactivateurs › SIX6 is a TAL1-regulated transcription factor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › SIX6 is a TAL1-regulated transcription factor...