Risk factors for frontal fibrosing alopecia: A case-control study in a multiracial population.
Adult
Aged
Alopecia
/ epidemiology
Brazil
/ epidemiology
Case-Control Studies
Cicatrix
/ epidemiology
Female
Forehead
Formaldehyde
/ adverse effects
Hair Preparations
/ adverse effects
Humans
Incidence
Male
Middle Aged
Prospective Studies
Protective Factors
Risk Assessment
/ statistics & numerical data
Risk Factors
Rosacea
/ epidemiology
Skin
/ pathology
Smoking
/ epidemiology
Soaps
/ adverse effects
Surveys and Questionnaires
/ statistics & numerical data
Thyroid Diseases
/ epidemiology
case-control
frontal fibrosing alopecia
risk factors
sunscreens
tobacco
Journal
Journal of the American Academy of Dermatology
ISSN: 1097-6787
Titre abrégé: J Am Acad Dermatol
Pays: United States
ID NLM: 7907132
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
12
05
2020
revised:
11
08
2020
accepted:
14
08
2020
pubmed:
25
8
2020
medline:
29
7
2021
entrez:
25
8
2020
Statut:
ppublish
Résumé
Frontal fibrosing alopecia (FFA) is a chronic cicatricial alopecia with unknown etiology and a worldwide rising incidence. The objective of this study was to evaluate the association of FFA with demographic and exposure factors in a Brazilian multiracial population. A multicenter case-control study was conducted in 11 referral centers throughout Brazil. The study was a case-control study that prospectively recruited 902 participants (451 patients with FFA and 451 sex-matched control individuals). Study participants completed a thorough questionnaire comprising variables grouped as baseline demographics, environmental exposure, diet, hormonal factors, allergies, and hair and skin care. When adjusted by sex, age, menopause, and skin color, FFA was associated with hair straightening with formalin (odds ratio [OR], 3.18), use of ordinary (nondermatologic) facial soap (OR, 2.09) and facial moisturizer (OR, 1.99), thyroid disorders (OR, 1.69), and rosacea (OR, 2.08). Smokers (OR, 0.33) and users of antiresidue/clarifying shampoo (OR, 0.35) presented a negative association with FFA. There was no association with the use of sunscreen. Recall bias. The association with moisturizers, ordinary facial soap, and hair straightening with formalin and the negative association with antiresidue/clarifying shampoo reinforce the possibility of an exogenous particle triggering FFA.
Sections du résumé
BACKGROUND
BACKGROUND
Frontal fibrosing alopecia (FFA) is a chronic cicatricial alopecia with unknown etiology and a worldwide rising incidence.
OBJECTIVE
OBJECTIVE
The objective of this study was to evaluate the association of FFA with demographic and exposure factors in a Brazilian multiracial population.
METHODS
METHODS
A multicenter case-control study was conducted in 11 referral centers throughout Brazil. The study was a case-control study that prospectively recruited 902 participants (451 patients with FFA and 451 sex-matched control individuals). Study participants completed a thorough questionnaire comprising variables grouped as baseline demographics, environmental exposure, diet, hormonal factors, allergies, and hair and skin care.
RESULTS
RESULTS
When adjusted by sex, age, menopause, and skin color, FFA was associated with hair straightening with formalin (odds ratio [OR], 3.18), use of ordinary (nondermatologic) facial soap (OR, 2.09) and facial moisturizer (OR, 1.99), thyroid disorders (OR, 1.69), and rosacea (OR, 2.08). Smokers (OR, 0.33) and users of antiresidue/clarifying shampoo (OR, 0.35) presented a negative association with FFA. There was no association with the use of sunscreen.
LIMITATIONS
CONCLUSIONS
Recall bias.
CONCLUSIONS
CONCLUSIONS
The association with moisturizers, ordinary facial soap, and hair straightening with formalin and the negative association with antiresidue/clarifying shampoo reinforce the possibility of an exogenous particle triggering FFA.
Identifiants
pubmed: 32835739
pii: S0190-9622(20)32472-5
doi: 10.1016/j.jaad.2020.08.076
pii:
doi:
Substances chimiques
Hair Preparations
0
Soaps
0
Formaldehyde
1HG84L3525
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
712-718Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2020 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.