Substantially thinner internal granular layer and reduced molecular layer surface in the cerebellar cortex of the Tc1 mouse model of down syndrome - a comprehensive morphometric analysis with active staining contrast-enhanced MRI.
Active staining
Cerebellar cortical laminar structure
Contrast-enhanced MRI
Cortical morphometric analysis
Cortical surface area
Cortical thickness
Cortical volume
Down syndrome
Tc1
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
24
04
2020
revised:
03
08
2020
accepted:
10
08
2020
pubmed:
25
8
2020
medline:
4
3
2021
entrez:
25
8
2020
Statut:
ppublish
Résumé
Down Syndrome is a chromosomal disorder that affects the development of cerebellar cortical lobules. Impaired neurogenesis in the cerebellum varies among different types of neuronal cells and neuronal layers. In this study, we developed an imaging analysis framework that utilizes gadolinium-enhanced ex vivo mouse brain MRI. We extracted the middle Purkinje layer of the mouse cerebellar cortex, enabling the estimation of the volume, thickness, and surface area of the entire cerebellar cortex, the internal granular layer, and the molecular layer in the Tc1 mouse model of Down Syndrome. The morphometric analysis of our method revealed that a larger proportion of the cerebellar thinning in this model of Down Syndrome resided in the inner granule cell layer, while a larger proportion of the surface area shrinkage was in the molecular layer.
Identifiants
pubmed: 32835824
pii: S1053-8119(20)30757-6
doi: 10.1016/j.neuroimage.2020.117271
pmc: PMC8417772
pii:
doi:
Substances chimiques
Contrast Media
0
Gadolinium
AU0V1LM3JT
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
117271Subventions
Organisme : Medical Research Council
ID : MR/G0900207-3/1
Pays : United Kingdom
Organisme : Department of Health
ID : BW.MN.BRC10269
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC001194
Pays : United Kingdom
Organisme : Medical Research Council
ID : U117527252
Pays : United Kingdom
Organisme : Medical Research Council
ID : FC001194
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K026739/1
Pays : United Kingdom
Organisme : Cancer Research UK
ID : FC001194
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/J013110/1
Pays : United Kingdom
Organisme : Cancer Research UK
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 098328
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/J01107X/1
Pays : United Kingdom
Organisme : Arthritis Research UK
ID : FC001194
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 080174
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 098327
Pays : United Kingdom
Organisme : CIHR
Pays : Canada
Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
Références
IEEE Trans Med Imaging. 1999 Oct;18(10):946-56
pubmed: 10628954
Neuroimage. 2004 Aug;22(4):1732-43
pubmed: 15275929
Neuroimage. 2012 Sep;62(3):1408-14
pubmed: 22658976
Nat Rev Neurosci. 2015 Sep;16(9):564-74
pubmed: 26243569
Neuroimage. 2015 Jan 15;105:473-85
pubmed: 25449739
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5019-21
pubmed: 10805761
Arch Neurol. 1997 Feb;54(2):209-12
pubmed: 9041863
Neuroimage. 2014 Jun;93 Pt 2:165-75
pubmed: 23567887
Cereb Cortex. 2018 Jul 1;28(7):2551-2562
pubmed: 29901791
Neural Dev. 2007 Dec 03;2:26
pubmed: 18053187
Med Image Anal. 2013 Aug;17(6):671-84
pubmed: 23510558
Neurobiol Aging. 2003 Jan-Feb;24(1):95-103
pubmed: 12493555
Hum Brain Mapp. 2020 Oct 1;41(14):4127-4147
pubmed: 32614505
Nature. 2017 Apr 6;544(7648):96-100
pubmed: 28321129
Neurology. 1997 Sep;49(3):786-94
pubmed: 9305341
Neuroimage. 2007 Feb 15;34(4):1317-30
pubmed: 17182260
Hum Brain Mapp. 2019 Apr 1;40(5):1507-1527
pubmed: 30431208
Cereb Cortex. 2012 Sep;22(9):2016-23
pubmed: 21983231
Neuroimage. 2012 Jul 16;61(4):1428-43
pubmed: 22446492
Neuroimage. 2014 Jun;93 Pt 2:157-64
pubmed: 23648963
AJNR Am J Neuroradiol. 2001 Sep;22(8):1483-9
pubmed: 11559495
NMR Biomed. 2013 Dec;26(12):1870-8
pubmed: 24142688
Cereb Cortex. 2016 Jul;26(7):2982-90
pubmed: 26088974
J Neurosci. 2013 Sep 25;33(39):15408-13
pubmed: 24068809
IEEE Trans Med Imaging. 1999 Aug;18(8):712-21
pubmed: 10534053
PLoS One. 2012;7(12):e53361
pubmed: 23300918
Brain. 2008 Mar;131(Pt 3):665-80
pubmed: 18263627
Front Neuroinform. 2012 Mar 23;6:6
pubmed: 22470335
IEEE Trans Med Imaging. 2003 Oct;22(10):1332-9
pubmed: 14552586
Methods Mol Biol. 2010;611:141-9
pubmed: 19960328
J Clin Exp Neuropsychol. 2012;34(1):35-56
pubmed: 22047489
Brain Topogr. 2013 Jan;26(1):9-23
pubmed: 22890700
Radiology. 2010 Mar;254(3):942-8
pubmed: 20177104
Hum Mol Genet. 2000 Jan 22;9(2):195-202
pubmed: 10607830
Neurobiol Aging. 2012 Mar;33(3):617.e1-9
pubmed: 20739099
Brain. 1998 Apr;121 ( Pt 4):561-79
pubmed: 9577385
Neuroimage. 2014 Jun;93 Pt 2:210-20
pubmed: 23603284
Brain. 2006 Feb;129(Pt 2):290-2
pubmed: 16434422
J Neurosci. 2011 Aug 10;31(32):11597-616
pubmed: 21832190
Magn Reson Med. 2013 Dec;70(6):1707-17
pubmed: 23400959
Harv Rev Psychiatry. 2006 May-Jun;14(3):141-51
pubmed: 16787886
Brain. 2006 Feb;129(Pt 2):306-20
pubmed: 16317024
Neuroimage. 2019 Aug 15;197:707-715
pubmed: 28942063
PLoS One. 2014 Jan 27;9(1):e86576
pubmed: 24475148
Elife. 2019 Nov 19;8:
pubmed: 31742552
Hum Mol Genet. 2009 Apr 15;18(8):1449-63
pubmed: 19181682
Neuroimage. 2008 Jun;41(2):243-51
pubmed: 18387826
Neuron. 2013 Oct 30;80(3):807-15
pubmed: 24183029
Neuropsychopharmacology. 2007 Oct;32(10):2229-37
pubmed: 17299505
Sci Rep. 2019 Jan 29;9(1):855
pubmed: 30696877
Autism Res. 2014 Feb;7(1):124-37
pubmed: 24151012
Neuroscience. 2005;135(4):1203-15
pubmed: 16165303
Neurobiol Dis. 2013 Jun;54:59-67
pubmed: 23454197
ScientificWorldJournal. 2014 Jan 06;2014:541802
pubmed: 24550710
IEEE Trans Med Imaging. 2000 Feb;19(2):143-50
pubmed: 10784285
Neuroimage. 2010 Nov 15;53(3):1135-46
pubmed: 20006715
Neuroimage. 2019 Aug 15;197:677-688
pubmed: 29309898
J Neurosci. 2012 Nov 14;32(46):16265-73
pubmed: 23152610
Neuroimage. 2008 Jan 1;39(1):238-47
pubmed: 17904870
Neurobiol Dis. 2018 Feb;110:206-217
pubmed: 29221819
Biol Psychiatry. 2012 Mar 15;71(6):552-60
pubmed: 22281121
Neuroimage. 2011 Jun 1;56(3):974-83
pubmed: 21310249
Hum Brain Mapp. 2013 Oct;34(10):2635-54
pubmed: 22611030
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3834-9
pubmed: 20133720
Sci Data. 2019 Oct 30;6(1):244
pubmed: 31666530
J Med Imaging (Bellingham). 2014 Jul;1(2):024003
pubmed: 26158035
Cardiovasc Res. 2010 Nov 1;88(2):287-95
pubmed: 20558441
Neurobiol Aging. 2012 Apr;33(4):828.e31-44
pubmed: 21843906
PLoS One. 2016 Sep 22;11(9):e0162974
pubmed: 27658297
Front Neurosci. 2020 Oct 22;14:853
pubmed: 33192235
Cereb Cortex. 2014 Oct;24(10):2541-52
pubmed: 23645712
Brain. 2018 Aug 1;141(8):2457-2474
pubmed: 29945247
J Anat. 2004 Feb;204(2):93-102
pubmed: 15032916
PLoS One. 2013 Apr 15;8(4):e60482
pubmed: 23596509
J Magn Reson Imaging. 2002 Oct;16(4):423-9
pubmed: 12353257
Neuroimage. 2010 Nov 1;53(2):365-72
pubmed: 20600960
Neuroimage. 2010 Nov 1;53(2):491-505
pubmed: 20620211
Brain Pathol. 2011 Jul;21(4):361-73
pubmed: 21040072
Acta Neuropathol Commun. 2019 Jan 7;7(1):4
pubmed: 30616676
Front Neuroinform. 2017 Mar 31;11:20
pubmed: 28408879
Neuroimage. 2011 Jan 15;54(2):769-78
pubmed: 20656039
J Neurosci. 2014 Jun 18;34(25):8488-98
pubmed: 24948804
Cereb Cortex. 2018 Feb 1;28(2):738-749
pubmed: 29190325
Neuroimage. 2005 Jul 1;26(3):839-51
pubmed: 15955494
Trends Neurosci. 2009 Jan;32(1):30-40
pubmed: 18977038
Neuroimage. 2009 Oct 1;47(4):1252-60
pubmed: 19520174
Science. 2005 Sep 23;309(5743):2033-7
pubmed: 16179473
Hum Mol Genet. 2009 Apr 15;18(R1):R75-83
pubmed: 19297404
Neurobiol Learn Mem. 2016 Apr;130:118-28
pubmed: 26868479
Neuroimage. 2013 Jan 15;65:336-48
pubmed: 23041529
Front Neurosci. 2019 Jan 24;13:11
pubmed: 30733665
Psychiatry Res. 2011 Aug 30;193(2):113-22
pubmed: 21684724
Neuroimage. 2004 Nov;23(3):997-1012
pubmed: 15528100
Prog Neurobiol. 2007 Jun;82(2):87-94
pubmed: 17408845