Tyrosinase-activated prodrug nanomedicine as oxidative stress amplifier for melanoma-specific treatment.

Glutathione / metabolism Humans Hydrogen Peroxide Melanoma / drug therapy Monophenol Monooxygenase / metabolism Nanomedicine Oxidative Stress Prodrugs / pharmacology Prospective Studies Reactive Oxygen Species
Acetaminophen Melanoma treatment Nano-prodrug Oxidative stress Tyrosinase activation

Journal

Biomaterials
ISSN: 1878-5905
Titre abrégé: Biomaterials
Pays: Netherlands
ID NLM: 8100316

Informations de publication

Date de publication:
11 2020
Historique:
received: 18 03 2020
revised: 10 08 2020
accepted: 13 08 2020
pubmed: 25 8 2020
medline: 15 5 2021
entrez: 25 8 2020
Statut: ppublish

Résumé

Malignant melanoma is one of the most aggressive skin cancers, posing severe threat to human health. Tyrosinase, overexpressed in melanoma cells, is a specific in-situ weapon to augment the therapeutic efficacy of melanoma-specific treatment by in-situ accelerating the activation of anti-melanoma prodrugs. Herein, we developed a tyrosinase-triggered oxidative stress amplifier, denoted as APAP@PEG/HMnO

Identifiants

DOI: 10.1016/j.biomaterials.2020.120329 PMID: 32836058
pubmed: 32836058
pii: S0142-9612(20)30575-5
doi: 10.1016/j.biomaterials.2020.120329
pii:
doi:

Substances chimiques

Prodrugs 0
Reactive Oxygen Species 0
Hydrogen Peroxide BBX060AN9V
Monophenol Monooxygenase EC 1.14.18.1
Glutathione GAN16C9B8O

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

120329

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Yinying Pu (Y)

Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment, Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University Cancer Center, Tongji University School of Medicine, Shanghai, 200072, PR China.

Bangguo Zhou (B)

Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment, Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University Cancer Center, Tongji University School of Medicine, Shanghai, 200072, PR China.

Huijing Xiang (H)

State Key Lab of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China. Electronic address: xianghuijing@mail.sic.ac.cn.

Wencheng Wu (W)

State Key Lab of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China.

Haohao Yin (H)

Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment, Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University Cancer Center, Tongji University School of Medicine, Shanghai, 200072, PR China.

Wenwen Yue (W)

Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment, Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University Cancer Center, Tongji University School of Medicine, Shanghai, 200072, PR China.

Yifei Yin (Y)

Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment, Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University Cancer Center, Tongji University School of Medicine, Shanghai, 200072, PR China.

Hongyan Li (H)

Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment, Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University Cancer Center, Tongji University School of Medicine, Shanghai, 200072, PR China.

Yu Chen (Y)

State Key Lab of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China; School of Life Sciences, Shanghai University, Shanghai, 200444, PR China. Electronic address: chenyuedu@shu.edu.cn.

Huixiong Xu (H)

Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment, Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University Cancer Center, Tongji University School of Medicine, Shanghai, 200072, PR China. Electronic address: xuhuixiong@126.com.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Oligopeptides › Glutathion › Tyrosinase-activated prodrug nanomedicine as...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Tyrosinase-activated prodrug nanomedicine as...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Tyrosinase-activated prodrug nanomedicine as...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Naevus et mélanomes › Mélanome › Tyrosinase-activated prodrug nanomedicine as...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Mixed function oxygenases › Catechol oxidase › Monophenol monooxygenase › Tyrosinase-activated prodrug nanomedicine as...
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Miniaturisation › Nanotechnologie › Nanomédecine › Tyrosinase-activated prodrug nanomedicine as...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Tyrosinase-activated prodrug nanomedicine as...
questionsmedicales.fr › Préparations pharmaceutiques › Promédicaments › Tyrosinase-activated prodrug nanomedicine as...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Tyrosinase-activated prodrug nanomedicine as...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Tyrosinase-activated prodrug nanomedicine as...