The COVID-19 Drug and Gene Set Library.

DSML 3: Development/Pre-production: Data science output has been rolled out/validated across multiple domains/problems

Journal

Patterns (New York, N.Y.)
ISSN: 2666-3899
Titre abrégé: Patterns (N Y)
Pays: United States
ID NLM: 101767765

Informations de publication

Date de publication:
11 Sep 2020
Historique:
received: 13 05 2020
revised: 05 07 2020
accepted: 22 07 2020
pubmed: 25 8 2020
medline: 25 8 2020
entrez: 25 8 2020
Statut: ppublish

Résumé

In a short period, many research publications that report sets of experimentally validated drugs as potential COVID-19 therapies have emerged. To organize this accumulating knowledge, we developed the COVID-19 Drug and Gene Set Library (https://amp.pharm.mssm.edu/covid19/), a collection of drug and gene sets related to COVID-19 research from multiple sources. The platform enables users to view, download, analyze, visualize, and contribute drug and gene sets related to COVID-19 research. To evaluate the content of the library, we compared the results from six

Identifiants

DOI: 10.1016/j.patter.2020.100090 PMID: 32838343 PMC: PMC7381899
pubmed: 32838343
doi: 10.1016/j.patter.2020.100090
pii: S2666-3899(20)30118-5
pii: 100090
pmc: PMC7381899
doi:

Types de publication

Journal Article

Langues

eng

Pagination

100090

Subventions

Organisme : NHLBI NIH HHS
ID : T32 HL007824
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA224260
Pays : United States
Organisme : NHLBI NIH HHS
ID : U54 HL127624
Pays : United States

Commentaires et corrections

Type : UpdateOf

Informations de copyright

© 2020 The Authors.

Déclaration de conflit d'intérêts

The authors declare no competing interests.

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Auteurs

Maxim V Kuleshov (MV)

Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Big Data to Knowledge, Library of Integrated Network-based Cellular Signatures, Data Coordination and Integration Center (BD2K-LINCS DCIC), Knowledge Management Center for Illuminating the Druggable Genome (KMC-IDG), Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA.

Daniel J Stein (DJ)

Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Big Data to Knowledge, Library of Integrated Network-based Cellular Signatures, Data Coordination and Integration Center (BD2K-LINCS DCIC), Knowledge Management Center for Illuminating the Druggable Genome (KMC-IDG), Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA.

Daniel J B Clarke (DJB)

Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Big Data to Knowledge, Library of Integrated Network-based Cellular Signatures, Data Coordination and Integration Center (BD2K-LINCS DCIC), Knowledge Management Center for Illuminating the Druggable Genome (KMC-IDG), Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA.

Eryk Kropiwnicki (E)

Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Big Data to Knowledge, Library of Integrated Network-based Cellular Signatures, Data Coordination and Integration Center (BD2K-LINCS DCIC), Knowledge Management Center for Illuminating the Druggable Genome (KMC-IDG), Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA.

Kathleen M Jagodnik (KM)

Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Big Data to Knowledge, Library of Integrated Network-based Cellular Signatures, Data Coordination and Integration Center (BD2K-LINCS DCIC), Knowledge Management Center for Illuminating the Druggable Genome (KMC-IDG), Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA.

Alon Bartal (A)

Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Big Data to Knowledge, Library of Integrated Network-based Cellular Signatures, Data Coordination and Integration Center (BD2K-LINCS DCIC), Knowledge Management Center for Illuminating the Druggable Genome (KMC-IDG), Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA.

John E Evangelista (JE)

Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Big Data to Knowledge, Library of Integrated Network-based Cellular Signatures, Data Coordination and Integration Center (BD2K-LINCS DCIC), Knowledge Management Center for Illuminating the Druggable Genome (KMC-IDG), Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA.

Jason Hom (J)

Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Big Data to Knowledge, Library of Integrated Network-based Cellular Signatures, Data Coordination and Integration Center (BD2K-LINCS DCIC), Knowledge Management Center for Illuminating the Druggable Genome (KMC-IDG), Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA.

Minxuan Cheng (M)

Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Big Data to Knowledge, Library of Integrated Network-based Cellular Signatures, Data Coordination and Integration Center (BD2K-LINCS DCIC), Knowledge Management Center for Illuminating the Druggable Genome (KMC-IDG), Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA.

Allison Bailey (A)

Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Big Data to Knowledge, Library of Integrated Network-based Cellular Signatures, Data Coordination and Integration Center (BD2K-LINCS DCIC), Knowledge Management Center for Illuminating the Druggable Genome (KMC-IDG), Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA.

Abigail Zhou (A)

Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Big Data to Knowledge, Library of Integrated Network-based Cellular Signatures, Data Coordination and Integration Center (BD2K-LINCS DCIC), Knowledge Management Center for Illuminating the Druggable Genome (KMC-IDG), Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA.

Laura B Ferguson (LB)

Department of Neurology, Dell Medical School, University of Texas at Austin, 1601 Trinity Street, Bldg B, Austin, TX 78712, USA.

Alexander Lachmann (A)

Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Big Data to Knowledge, Library of Integrated Network-based Cellular Signatures, Data Coordination and Integration Center (BD2K-LINCS DCIC), Knowledge Management Center for Illuminating the Druggable Genome (KMC-IDG), Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA.

Avi Ma'ayan (A)

Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Big Data to Knowledge, Library of Integrated Network-based Cellular Signatures, Data Coordination and Integration Center (BD2K-LINCS DCIC), Knowledge Management Center for Illuminating the Druggable Genome (KMC-IDG), Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA.

Classifications MeSH