Impact of COVID-19 on Alzheimer's Disease Risk: Viewpoint for Research Action.
ACE2
Alzheimer’s disease risk
SARS-CoV-2 infection
neuroinvasivness
Journal
Healthcare (Basel, Switzerland)
ISSN: 2227-9032
Titre abrégé: Healthcare (Basel)
Pays: Switzerland
ID NLM: 101666525
Informations de publication
Date de publication:
21 Aug 2020
21 Aug 2020
Historique:
received:
18
07
2020
revised:
14
08
2020
accepted:
18
08
2020
entrez:
26
8
2020
pubmed:
26
8
2020
medline:
26
8
2020
Statut:
epublish
Résumé
In the middle of the coronavirus disease 19 (COVID-19) outbreak, the main efforts of the scientific community are rightly all focused on identifying efficient pharmacological treatments to cure the acute severe symptoms and developing a reliable vaccine. On the other hand, we cannot exclude that, in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) positive subjects, the virus infection could have long-term consequences, leading to chronic medical conditions such as dementia and neurodegenerative disease. Considering the age of SARS-CoV-2 infected subjects, the neuroinvasive potential might lead/contribute to the development of neurodegenerative diseases. Here, we analyzed a possible link between SARS-CoV-2 infection and Alzheimer's disease risk, hypothesizing possible mechanisms at the base of disease development. This reflection raises the need to start to experimentally investigating today the mechanistic link between Alzheimer's disease (AD) and COVID-19 to be ready tomorrow.
Identifiants
pubmed: 32839380
pii: healthcare8030286
doi: 10.3390/healthcare8030286
pmc: PMC7551579
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : University intramural funding grant to D. Uberti.
Références
Neurochem Res. 2019 Jun;44(6):1323-1329
pubmed: 30443713
Circ Res. 2000 Sep 1;87(5):E1-9
pubmed: 10969042
Hypertension. 2004 Nov;44(5):783-7
pubmed: 15381673
Immun Ageing. 2008 Aug 13;5:7
pubmed: 18700965
Am J Physiol. 1992 Jul;263(1 Pt 2):R89-94
pubmed: 1636797
BMJ. 2010 Jan 12;340:b5465
pubmed: 20068258
J Comp Neurol. 2013 Jan 1;521(1):203-12
pubmed: 22700307
Alzheimers Dement. 2018 Apr;14(4):535-562
pubmed: 29653606
Ann Neurol. 1999 Mar;45(3):358-68
pubmed: 10072051
J Alzheimers Dis. 2020;76(1):3-19
pubmed: 32538857
Neurobiol Aging. 2000 May-Jun;21(3):383-421
pubmed: 10858586
Eur J Neurol. 2010 Oct;17(10):1236-48
pubmed: 20831773
FEBS Lett. 2012 Oct 19;586(20):3737-45
pubmed: 22982863
Aging Ment Health. 2020 Feb;24(2):197-199
pubmed: 30600688
Cardiovasc Res. 2011 Dec 1;92(3):401-8
pubmed: 21952934
Nature. 2020 May;581(7806):71-76
pubmed: 32376954
Brain Res. 2014 Jul 21;1573:44-53
pubmed: 24854124
Oxid Med Cell Longev. 2017;2017:7039816
pubmed: 28168012
Hypertension. 2009 Feb;53(2):210-6
pubmed: 19124678
Cold Spring Harb Perspect Med. 2011 Sep;1(1):a006189
pubmed: 22229116
Alzheimers Dement (N Y). 2017 May 24;3(3):367-384
pubmed: 29067343
J Intern Med. 2004 Sep;256(3):183-94
pubmed: 15324362
J Neuroinflammation. 2016 Jun 02;13(1):135
pubmed: 27256292
Regul Pept. 2008 Feb 7;146(1-3):58-66
pubmed: 17850902
J Physiol Pharmacol. 2003 Sep;54(3):371-81
pubmed: 14566076
Eur J Neurol. 2018 Jan;25(1):59-70
pubmed: 28872215
EMBO Mol Med. 2016 Jun 01;8(6):595-608
pubmed: 27025652
Nat Med. 2020 Jun;26(6):842-844
pubmed: 32398875
Neurobiol Learn Mem. 2012 Jan;97(1):113-23
pubmed: 22067210
J Virol. 2008 Aug;82(15):7264-75
pubmed: 18495771
Vet Pathol. 2004 Mar;41(2):101-7
pubmed: 15017022
Eur Arch Otorhinolaryngol. 2020 Aug;277(8):2251-2261
pubmed: 32253535
Alzheimers Res Ther. 2016 Jul 30;8(1):23
pubmed: 27473681
J Alzheimers Dis. 2015;48(2):319-53
pubmed: 26401998
Hypertension. 2000 Jun;35(6):1248-52
pubmed: 10856272
Brain Res. 2004 Oct 29;1025(1-2):186-93
pubmed: 15464759
Hypertension. 1995 Jun;25(6):1260-5
pubmed: 7768571
Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R373-81
pubmed: 16946085
Neuron. 2019 Dec 18;104(6):1034-1035
pubmed: 31855626
Neuropathol Appl Neurobiol. 2019 Jun;45(4):327-346
pubmed: 30394574
Oxid Med Cell Longev. 2016;2016:7205747
pubmed: 28096943
J Virol. 2004 Apr;78(7):3398-406
pubmed: 15016862
J Am Geriatr Soc. 2015 Sep;63(9):1749-56
pubmed: 26389987
Science. 1993 Aug 13;261(5123):921-3
pubmed: 8346443
J Infect Dis. 2016 Mar 1;213(5):712-22
pubmed: 26486634
Lancet. 1997 Jan 25;349(9047):241-4
pubmed: 9014911
Acta Neuropathol. 2020 Mar;139(3):485-502
pubmed: 31982938
Virus Res. 2012 Feb;163(2):628-35
pubmed: 22248641
Neurology. 2020 Aug 18;95(7):e910-e920
pubmed: 32444493
Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8258-63
pubmed: 12829792
Neurotherapeutics. 2010 Oct;7(4):354-65
pubmed: 20880500
J Pathol. 2004 Jun;203(2):631-7
pubmed: 15141377
Neurobiol Dis. 2019 Oct;130:104481
pubmed: 31136814
Free Radic Biol Med. 2018 Dec;129:430-439
pubmed: 30321702
Biochim Biophys Acta. 2014 Aug;1842(8):1248-57
pubmed: 24120836
Br J Pharmacol. 2019 Sep;176(18):3489-3507
pubmed: 30675901
J Gerontol A Biol Sci Med Sci. 2020 Oct 15;75(11):2231-2232
pubmed: 32451547
Mol Cell Neurosci. 2005 Jul;29(3):427-35
pubmed: 15950155
Lancet Infect Dis. 2020 May;20(5):553-558
pubmed: 32171059
Ther Adv Neurol Disord. 2010 May;3(3):141-52
pubmed: 21179606
Int J Infect Dis. 2020 May;94:55-58
pubmed: 32251791
Neuron. 2009 Oct 15;64(1):17-20
pubmed: 19840542
J Hypertens. 1998 Dec;16(12 Pt 1):1797-804
pubmed: 9869014
Brain Res Bull. 2017 Jul;133:88-96
pubmed: 27316747
Science. 2020 Mar 27;367(6485):1444-1448
pubmed: 32132184
Arch Intern Med. 2012 Mar 12;172(5):442-4
pubmed: 22412114
Int J Geriatr Psychiatry. 2006 Jun;21(6):550-5
pubmed: 16642542
Brain Res. 1998 Mar 2;785(2):195-206
pubmed: 9518610
Brain Res. 2008 Jul 11;1219:127-35
pubmed: 18538311
Lancet Neurol. 2020 Sep;19(9):767-783
pubmed: 32622375
Circ Res. 2008 Mar 28;102(6):729-36
pubmed: 18258853
Alzheimers Res Ther. 2020 Jun 4;12(1):69
pubmed: 32498691
Eur J Pharmacol. 2006 Sep 1;545(1):39-50
pubmed: 16860790
CNS Neurosci Ther. 2014 May;20(5):452-9
pubmed: 24581232
Front Aging Neurosci. 2018 Oct 19;10:324
pubmed: 30405395
Healthcare (Basel). 2020 Jul 24;8(3):
pubmed: 32722174
Nat Med. 2020 May;26(5):681-687
pubmed: 32327758
PLoS One. 2010 Mar 03;5(3):e9505
pubmed: 20209079
Am J Physiol. 1994 Sep;267(3 Pt 2):R786-91
pubmed: 8092324
JAMA Neurol. 2020 Jun 1;77(6):683-690
pubmed: 32275288
Clin Sci (Lond). 2014 Feb;126(3):195-205
pubmed: 24102099
J Neuroimmunol. 1993 Jul;46(1-2):19-24
pubmed: 7689587
J Pathol. 2004 Jul;203(3):740-3
pubmed: 15221932