Effects of Omega 3 Fatty Acids on Main Dimensions of Psychopathology.
Affective Symptoms
/ drug therapy
Antipsychotic Agents
/ therapeutic use
Attention Deficit Disorder with Hyperactivity
/ drug therapy
Autism Spectrum Disorder
/ drug therapy
Bipolar Disorder
/ drug therapy
Depressive Disorder, Major
/ drug therapy
Dietary Supplements
Fatty Acids, Omega-3
/ therapeutic use
Humans
Personality Disorders
/ drug therapy
Psychopathology
/ methods
Psychotic Disorders
/ drug therapy
Randomized Controlled Trials as Topic
Suicidal Ideation
PUFAs
affectivity
impulsivity
omega-3 fatty acids
psychiatric disorders
psychosis
self-harm behaviors
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 Aug 2020
21 Aug 2020
Historique:
received:
17
07
2020
revised:
11
08
2020
accepted:
19
08
2020
entrez:
26
8
2020
pubmed:
26
8
2020
medline:
23
2
2021
Statut:
epublish
Résumé
The usefulness of polyunsaturated fatty acids on inflammatory, cardiovascular, and the nervous system was studied in the last decades, but the mechanisms underlying their benefic properties are still partially unknown. These agents seem to express their action on the membrane phospholipid composition and permeability and modulation of second messenger cascades. In psychiatry, the efficacy and tolerability of omega-3 fatty acids were investigated in several psychiatric disorders, including major depression, bipolar disorder, personality disorders, high-risk conditions to develop psychosis, attention-deficit hyperactivity disorder, and autism spectrum disorders. Initial findings in this field are promising, and some relevant questions need to be addressed. In particular, the effects of these agents on the main symptom dimensions have to be investigated in a trans-diagnostic perspective. The present systematic review is aimed to examine the available data on the efficacy of omega-3 fatty acids on domains of psychotic symptoms, affective symptoms, impulsivity, and aggressiveness, and harmful behaviors, and suicide risk.
Identifiants
pubmed: 32839416
pii: ijms21176042
doi: 10.3390/ijms21176042
pmc: PMC7504659
pii:
doi:
Substances chimiques
Antipsychotic Agents
0
Fatty Acids, Omega-3
0
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Références
Annu Rev Food Sci Technol. 2018 Mar 25;9:345-381
pubmed: 29350557
Biol Psychiatry. 2006 Nov 1;60(9):1020-2
pubmed: 16814257
Cochrane Database Syst Rev. 2008 Apr 16;(2):CD005169
pubmed: 18425912
J Clin Psychiatry. 2005 Dec;66(12):1613-4
pubmed: 16401167
Am J Clin Nutr. 1999 Sep;70(3 Suppl):560S-569S
pubmed: 10479232
Psychiatry Res. 2009 Nov 30;174(2):81-8
pubmed: 19833485
Schizophr Res. 2018 May;195:283-285
pubmed: 28830741
J Nutr Health Aging. 2011 Jan;15(1):37-44
pubmed: 21267525
Front Aging Neurosci. 2015 Apr 21;7:52
pubmed: 25954194
Dev Med Child Neurol. 2000 Mar;42(3):174-81
pubmed: 10755457
Int J Mol Sci. 2017 Dec 04;18(12):
pubmed: 29207548
Am J Psychiatry. 2003 May;160(5):996-8
pubmed: 12727707
J Psychiatr Res. 2014 Oct;57:133-40
pubmed: 25017608
Brain Res. 2007 Nov 28;1182:50-9
pubmed: 17950710
Curr Psychiatry Rep. 2018 Apr 5;20(5):32
pubmed: 29623453
PLoS One. 2011;6(12):e28502
pubmed: 22174823
J Nutr Biochem. 2013 Dec;24(12):2127-37
pubmed: 24139673
Schizophr Res. 2014 Sep;158(1-3):230-5
pubmed: 24996507
Am J Obstet Gynecol. 2003 May;188(5):1348-53
pubmed: 12748510
Lancet. 2005 Oct 22-28;366(9495):1471-83
pubmed: 16243093
Eur J Neurosci. 2019 Nov 17;:
pubmed: 31736197
Am J Psychiatry. 2006 Jun;163(6):1100-2
pubmed: 16741213
Prostaglandins Other Lipid Mediat. 2012 Mar;97(3-4):73-82
pubmed: 22326554
Psychiatry Res. 2015 Sep 30;229(1-2):485-9
pubmed: 26188642
Can J Psychiatry. 2013 Jul;58(7):402-8
pubmed: 23870722
J Neurosci Res. 2008 Mar;86(4):776-84
pubmed: 17941053
Neuromolecular Med. 2016 Sep;18(3):426-40
pubmed: 27250850
J Clin Psychiatry. 2018 Jun 26;79(4):
pubmed: 29985566
Eur Arch Psychiatry Clin Neurosci. 2011 Dec;261(8):539-49
pubmed: 21318452
J Psychiatr Res. 2018 Sep;104:16-23
pubmed: 29920417
Free Radic Biol Med. 2008 Sep 1;45(5):726-31
pubmed: 18554520
Psychiatry Res. 2003 Aug 30;120(1):29-35
pubmed: 14500111
Am J Psychiatry. 2003 Jan;160(1):167-9
pubmed: 12505817
Psychiatry Res. 2018 Mar;261:307-311
pubmed: 29331711
Mol Aspects Med. 2018 Dec;64:18-33
pubmed: 30244005
J Clin Psychopharmacol. 2012 Oct;32(5):699-703
pubmed: 22926607
Drug Alcohol Depend. 2003 Sep 10;71(3):319-23
pubmed: 12957349
J Nutr. 1998 Dec;128(12):2505-11
pubmed: 9868200
Schizophr Res. 1994 Oct;13(3):195-207
pubmed: 7841132
Am J Obstet Gynecol. 2013 Apr;208(4):313.e1-9
pubmed: 23531328
Aust N Z J Psychiatry. 2008 Mar;42(3):199-205
pubmed: 18247194
J Affect Disord. 2008 Sep;110(1-2):142-8
pubmed: 18206247
J Affect Disord. 2019 Feb 15;245:364-370
pubmed: 30423463
Am J Clin Nutr. 2009 Feb;89(2):641-51
pubmed: 19116322
Am J Psychiatry. 2001 Dec;158(12):2071-4
pubmed: 11729030
Psychopharmacology (Berl). 2019 Apr;236(4):1273-1279
pubmed: 30519766
Am J Psychiatry. 2006 Jun;163(6):1098-100
pubmed: 16741212
Prostaglandins Leukot Essent Fatty Acids. 2005 Mar;72(3):211-8
pubmed: 15664306
Neuroscience. 2007 Aug 24;148(2):421-31
pubmed: 17683870
J Clin Psychiatry. 2007 Dec;68(12):1867-75
pubmed: 18162017
Int J Psychiatry Clin Pract. 2013 Jun;17(2):139-43
pubmed: 22809130
Psychiatr Serv. 2019 Jul 1;70(7):569-577
pubmed: 31084291
BMC Psychiatry. 2020 Mar 6;20(1):109
pubmed: 32143672
Lancet. 1971 Jun 5;1(7710):1143-5
pubmed: 4102857
Arch Gen Psychiatry. 2010 Feb;67(2):146-54
pubmed: 20124114
World Rev Nutr Diet. 2009;99:17-30
pubmed: 19136836
Int J Mol Sci. 2019 Oct 23;20(21):
pubmed: 31652770
Schizophr Res. 2006 May;84(1):112-20
pubmed: 16632329
J Clin Psychiatry. 2011 Dec;72(12):1585-90
pubmed: 21903029
Arch Psychiatr Nurs. 2008 Oct;22(5):305-11
pubmed: 18809123
Am J Psychiatry. 2002 Sep;159(9):1596-8
pubmed: 12202284
Arch Gen Psychiatry. 2001 May;58(5):512-3
pubmed: 11343534
Br J Psychiatry. 2006 Jan;188:46-50
pubmed: 16388069
JAMA. 2010 Oct 20;304(15):1675-83
pubmed: 20959577
Brain Res. 2015 Aug 18;1617:113-25
pubmed: 25003554
J Psychiatr Res. 2002 Jan-Feb;36(1):7-18
pubmed: 11755456
J Neurosci. 1995 Dec;15(12):7929-39
pubmed: 8613731
J Clin Psychiatry. 2011 Dec;72(12):1577-84
pubmed: 21939614
Prostaglandins Leukot Essent Fatty Acids. 2003 Dec;69(6):461-6
pubmed: 14623500
Eur Neuropsychopharmacol. 2013 Jul;23(7):636-44
pubmed: 22910528
J Clin Med. 2016 Jul 27;5(8):
pubmed: 27472373
J Clin Psychiatry. 2015 Jan;76(1):54-61
pubmed: 25272149
Altern Med Rev. 2007 Sep;12(3):207-27
pubmed: 18072818
J Psychiatr Res. 2018 Dec;107:48-56
pubmed: 30317101
Schizophr Res. 2001 Apr 30;49(3):243-51
pubmed: 11356585
Altern Med Rev. 2003 Nov;8(4):410-25
pubmed: 14653768
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):568-75
pubmed: 18060675
Front Immunol. 2019 Apr 24;10:837
pubmed: 31068933
CNS Neurol Disord Drug Targets. 2018;17(3):216-232
pubmed: 29651972
Am J Psychiatry. 2002 Mar;159(3):477-9
pubmed: 11870016
Auton Autacoid Pharmacol. 2008 Jan;28(1):41-58
pubmed: 18257750
Prog Neuropsychopharmacol Biol Psychiatry. 2007 Oct 1;31(7):1393-6
pubmed: 17659823
Ir J Psychol Med. 2017 Jun;34(2):117-126
pubmed: 30115215
Ann Nutr Metab. 2015;66(2-3):141-8
pubmed: 25824637
Dev Neurosci. 2009;31(3):181-92
pubmed: 19145070
J Psychopharmacol. 2014 Feb;28(2):125-32
pubmed: 24196948
J Neurol Sci. 1978 Jul;37(3):249-66
pubmed: 681979
J Psychiatr Res. 2016 Feb;73:34-44
pubmed: 26679763
Brain Res. 2007 Feb 16;1133(1):42-8
pubmed: 17184749
Lancet. 1998 Aug 29;352(9129):688-91
pubmed: 9728984
Prostaglandins Leukot Essent Fatty Acids. 2008 Apr-May;78(4-5):311-26
pubmed: 18514501
J Affect Disord. 2014 Jan;152-154:76-82
pubmed: 23726775
J Clin Psychiatry. 2009 Dec;70(12):1636-44
pubmed: 19709502
J Clin Med. 2016 Aug 03;5(8):
pubmed: 27527228
Br J Nutr. 2008 Feb;99(2):421-31
pubmed: 17956647
Contemp Clin Trials. 2016 Mar;47:325-33
pubmed: 26855120
Prostaglandins Leukot Essent Fatty Acids. 2017 Jun;121:7-13
pubmed: 28651701
Clin Drug Investig. 2018 Apr;38(4):367-372
pubmed: 29302857
Br J Psychiatry. 2007 Feb;190:118-22
pubmed: 17267927
Australas Psychiatry. 2017 Apr;25(2):117-120
pubmed: 28375061
Psychopharmacol Bull. 2009;42(3):39-54
pubmed: 19752840
J Affect Disord. 2018 Dec 1;241:200-205
pubmed: 30130685
J Am Acad Child Adolesc Psychiatry. 2013 Oct;52(10):1038-47
pubmed: 24074470
FASEB J. 2015 Jun;29(6):2207-22
pubmed: 25713056
Brain Behav Immun. 2020 Aug;88:529-534
pubmed: 32304881
Biochim Biophys Acta. 2015 Apr;1851(4):469-84
pubmed: 25149823
JAMA Psychiatry. 2017 Jan 1;74(1):19-27
pubmed: 27893018
Transl Psychiatry. 2016 Sep 20;6(9):e897
pubmed: 27648919
J Nutr Biochem. 2016 Dec;38:1-11
pubmed: 27825512
Trends Neurosci. 2004 Oct;27(10):589-94
pubmed: 15374669
Nutr J. 2012 Oct 10;11:82
pubmed: 23046564
Biol Psychiatry. 1987 Sep;22(9):1087-96
pubmed: 2958095
Behav Brain Res. 2008 Aug 5;191(1):11-6
pubmed: 18423905
J Clin Psychiatry. 2016 Oct;77(10):e1301-e1308
pubmed: 27631140
Glob J Health Sci. 2014 Sep 18;6(7 Spec No):103-8
pubmed: 25363186
Tohoku J Exp Med. 2017;242(3):203-213
pubmed: 28724853
Psychiatry Res. 2010 May 30;182(2):180-2
pubmed: 20413278
PLoS One. 2014 May 07;9(5):e96905
pubmed: 24805797
Psychiatr Pol. 2012 Jul-Aug;46(4):585-98
pubmed: 23214161
J Neural Transm (Vienna). 2020 May 25;:
pubmed: 32451632
J Child Adolesc Psychopharmacol. 2015 Sep;25(7):526-34
pubmed: 26288263
J Anxiety Disord. 2015 Mar;30:34-40
pubmed: 25591045
Br J Nutr. 2012 Jun;107 Suppl 2:S85-106
pubmed: 22591907
J Clin Psychiatry. 2011 Aug;72(8):1054-62
pubmed: 20584525
Biol Psychiatry. 2010 Jul 15;68(2):140-7
pubmed: 20452573
J Child Neurol. 2012 Jun;27(6):747-53
pubmed: 22596014
J Clin Psychopharmacol. 2006 Dec;26(6):661-5
pubmed: 17110827
J Neuroinflammation. 2016 Mar 10;13(1):61
pubmed: 26965310
Arch Gen Psychiatry. 2002 Oct;59(10):913-9
pubmed: 12365878
Psychiatry Res. 2008 Sep 30;160(3):285-99
pubmed: 18715653
Psychosom Med. 2017 Jun;79(5):549-556
pubmed: 28121722
PLoS One. 2018 May 7;13(5):e0197231
pubmed: 29734367
J Biol Chem. 2003 Oct 31;278(44):43807-17
pubmed: 12923200
Depress Anxiety. 2014 Nov;31(11):906-8
pubmed: 25407578
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Feb 1;33(1):49-52
pubmed: 18955102
J Clin Psychopharmacol. 2012 Feb;32(1):61-4
pubmed: 22198441
J Psychopharmacol. 2012 May;26(5):738-43
pubmed: 22004690
J Nutr. 2012 Mar;142(3):592S-599S
pubmed: 22279140
Am J Psychiatry. 2004 Oct;161(10):1922-4
pubmed: 15465995
J Neurotrauma. 2010 Oct;27(10):1769-80
pubmed: 20698757
Neuropsychopharmacology. 2008 Sep;33(10):2467-73
pubmed: 18199999
Psychiatr Pol. 2017 Apr 30;51(2):323-334
pubmed: 28581540
Neuromolecular Med. 2018 Sep;20(3):328-342
pubmed: 29846873
Clin Ter. 2013;164(6):e529-37
pubmed: 24424237
Nat Commun. 2015 Aug 11;6:7934
pubmed: 26263244
Arch Gen Psychiatry. 1999 May;56(5):407-12
pubmed: 10232294
J Am Coll Nutr. 2010 Feb;29(1):55-64
pubmed: 20595646
Eur Neuropsychopharmacol. 2006 Feb;16(2):107-13
pubmed: 16243493
J Lipid Res. 2006 Jan;47(1):172-80
pubmed: 16210728
Biochim Biophys Acta. 2015 Feb;1851(2):203-9
pubmed: 25450447
Eur Neuropsychopharmacol. 2003 Aug;13(4):267-71
pubmed: 12888186
Mol Psychiatry. 2014 Mar;19(3):317-24
pubmed: 23478748
J Abnorm Child Psychol. 2017 Jul;45(5):1025-1037
pubmed: 27604240
Prostaglandins Leukot Essent Fatty Acids. 2006 Oct-Nov;75(4-5):259-69
pubmed: 16963244
Bipolar Disord. 2010 Mar;12(2):142-54
pubmed: 20402707
Schizophr Res. 2012 Nov;141(2-3):153-61
pubmed: 22981812
Neurosci Biobehav Rev. 2016 Oct;69:147-58
pubmed: 27450580
Transl Psychiatry. 2013 Dec 17;3:e335
pubmed: 24346133
Psychiatr Clin North Am. 2013 Mar;36(1):15-23
pubmed: 23538073
Aust N Z J Psychiatry. 2008 Mar;42(3):192-8
pubmed: 18247193
Neurosurgery. 2011 Feb;68(2):474-81; discussion 481
pubmed: 21135750
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Apr 20;83:142-148
pubmed: 29241838
J Mol Neurosci. 2005;27(1):137-45
pubmed: 16055952
J Clin Psychiatry. 2012 Jan;73(1):81-6
pubmed: 21903025