Comparative analysis of racial differences in breast tumor microbiome.
Adult
Black or African American
/ statistics & numerical data
Aged
Biodiversity
Ethnicity
/ statistics & numerical data
Female
Hispanic or Latino
Humans
Microbiota
/ genetics
Middle Aged
RNA, Ribosomal, 16S
/ genetics
Receptor, ErbB-2
/ metabolism
Receptors, Estrogen
/ metabolism
Receptors, Progesterone
/ metabolism
Retrospective Studies
Triple Negative Breast Neoplasms
/ epidemiology
White People
/ statistics & numerical data
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
24 08 2020
24 08 2020
Historique:
received:
28
03
2020
accepted:
10
08
2020
entrez:
26
8
2020
pubmed:
26
8
2020
medline:
8
1
2021
Statut:
epublish
Résumé
Studies have demonstrated that environmental, host genetic, and socioeconomic factors influence the breast cancer prevalence landscape with a far-reaching influence on racial disparity to subtypes of breast cancer. To understand whether breast tissue harbors race-specific microbiota, we performed 16S rRNA gene-based sequencing of retrospective tumor and matched normal tissue adjacent to tumor (NAT) samples collected from Black non-Hispanic (BNH) and White non-Hispanic (WNH) women. Analysis of Triple Negative Breast cancer (TNBC) and Triple Positive Breast Cancer (TPBC) tissues for microbiota composition revealed significant differences in relative abundance of specific taxa at both phylum and genus levels between WNH and BNH women cohorts. Our main findings are that microbial diversity as measured by Shannon index was significantly lower in BNH TNBC tumor tissue as compared to matched NAT zone. In contrast, the WNH cohort had an inverse pattern for the Shannon index, when TNBC tumor tissue was compared to the matched NAT. Unweighted Principle Coordinates Analysis (PCoA) revealed a distinct clustering of tumor and NAT microbiota in both BNH and WNH cohorts.
Identifiants
pubmed: 32839514
doi: 10.1038/s41598-020-71102-x
pii: 10.1038/s41598-020-71102-x
pmc: PMC7445256
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
Receptors, Estrogen
0
Receptors, Progesterone
0
ERBB2 protein, human
EC 2.7.10.1
Receptor, ErbB-2
EC 2.7.10.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
14116Subventions
Organisme : NIH HHS
ID : S21MD012472
Pays : United States
Organisme : NIH HHS
ID : RO1CA220273
Pays : United States
Organisme : NIMHD NIH HHS
ID : U54 MD006882
Pays : United States
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